Sanofi tests H7N1 flu vaccine for pandemic readiness

first_imgSep 19, 2006 (CIDRAP News) – Sanofi Pasteur today announced the start of the first clinical trial of an H7N1 influenza vaccine, intended to guard against the threat of a pandemic caused by H7 strains of avian influenza.Current concern about a flu pandemic focuses mainly on the H5N1 avian flu virus, which has infected at least 247 people and killed 144. But H7 avian flu viruses have caused a number of mild illness cases and one death in the past 3 years.Sanofi Pasteur, part of the Sanofi-Aventis Group, said it launched a phase 1 trial of its H7N1 vaccine today at the University of Bergen in Norway. The vaccine is a split-virus product grown in cell culture rather than in eggs, the method usually used to produce flu vaccines.Development of the H7N1 vaccine is part of a European Union (EU) collaborative effort, called FLUPAN, to boost pandemic preparedness in the EU.”A highly pathogenic H7N1 avian influenza virus which caused outbreaks in Italian poultry in 1999 has been modified so that it is safe to use and grows well in mammalian cell culture,” FLUPAN coordinator Dr. John Wood said in a Sanofi news release.He said the vaccine virus was developed by the United Kingdom’s (UK’s) National Institute for Biological Standards and Control and the University of Reading, which are two of six partners in FLUPAN. The others are Sanofi Pasteur, the University of Bergen, Italy’s Istituto Superiore di Sanita, and the UK Health Protection Agency.The trial involves 60 healthy people between the ages of 20 and 40, who will receive two doses of either 12 or 24 micrograms of the vaccine, with or without an aluminum hydroxide adjuvant (immune response booster), said Dr. Lars R. Haaheim of the University of Bergen.H7 avian flu viruses that have infected humans include the H7N7 strain that swept through Dutch poultry farms in 2003, forcing the destruction of about 30 million birds. The virus infected 89 people and caused generally mild symptoms, but one veterinarian died. In addition, two people were infected and suffered mild flu-like illnesses during a poultry outbreak of highly pathogenic H7N3 virus in British Columbia, Canada, in early 2004.Also, a few Italian poultry workers were found to have antibodies to H7N1 and H7N3 viruses when they were tested in connection with avian flu outbreaks that occurred in Italy in 2002 and 2003. The workers did not report any flu-like illness at the time, but one reported conjunctivitis, according to a report in the Journal of Infectious Diseases in October 2005.”While most vaccine development has focused on H5N1 strains, avian H7–containing viruses remain a significant pandemic threat and have caused infections in humans in Europe over the last three years,” the Sanofi release says.H5N1 and H7N1 are not the only avian flu strains considered to have current pandemic potential. Chiron Corp., now part of Novartis, is developing an experimental H9N2 vaccine under a contract with the US government. That strain caused serious illness in three people in Hong Kong in 1999 and 2003.Sanofi Pasteur is producing an experimental H5N1 vaccine for the US government under a $150 million contract awarded in September 2005.See also:Sanofi Pasteur site with link to Sep 19 news release (click on “Sanofi broadens preparedness with first clinical trial of novel cell based H7N1 vaccine”)http://en.sanofi-aventis.com/Emerging Infectious Diseases report in December 2004 on human illness from H7N3 avian flu in British Columbiahttp://www.cdc.gov/ncidod/EID/vol10no12/04-0961.htmSep 13, 2005, CIDRAP News story on Italian poultry workers with antibodies to H7N1 and H7N3 avian flu viruses: “Low-pathogenic avian flu viruses can infect humans”Jul 27, 2005, CIDRAP News story “Momentum builds for cell-culture flu vaccines”last_img read more

admin

League of Women Voters to hold open forums ahead of presidential primaries

first_imgAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisALPENA, Mich. — If you’re interested in learning about your rights ahead of the presidential primary, the League of Women voters has you covered.The organization will hold three public forums in the next two months to educate community members. The first will be a formal–style town hall meeting that will address changes in voting laws, the census, and redistricting They’ll also hold an open house on February 14 to celebrate women’s 100th year of having the freedom to vote and they’ll inform residents on topics such as absentee voting. The last meeting is a collaboration with the Association of Lifelong Learners that will be held on February 19.You can find more times, dates, and information at www.lwvalpenacounty.orgAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThis Tags: ACC, elections, League of Women Voter, League of Women Voters, LWV, presidential primaries, primaries, primary, VotingContinue ReadingPrevious Hillman woman gets chance at the Michigan Lottery’s “Big Spin”Next City of Alpena Fire Chief explains reason for flames at DPIlast_img read more

admin

David Duncan: Kpando scoreline not true reflection of Kotoko game

first_imgHead Coach of Kumasi Asante Kotoko, David Duncan has blamed his team’s wastefulness in front of goal as the contributing factor to his team’s defeat in Kpando on Sunday. The tough talking coach lamented clear cut misses earlier on in the game as the major turning point in their league fixture.The Porcupines lost 3-1 in Kpando as they failed to complete a double over Hears of Lions in the league.“There were parts of the game, especially in the first quarter, where I feel we controlled and we were virtually on top,” said the manager at the post-match press conference.“In one instance I thought that we should have earned a penalty which the referee did not give and I also thought that the best chance of the game fell to Ahmed Toure which I think indiscretion made us lose the opportunity of going ahead to take the lead”.”So by the 30th minute or second quarter of the first half before Hearts of Lions took their lead, I think we should have been two goals up,” he told Asempa FM.”And in my opinion under that kind of situation the whole complexion of the game could have changed so 3-1 is not a true reflection of the game and I think that we did not utilize our chances”. The defeat leaves the Reds in eighth, seven points adrift of Ashantigold who have a game in hand and further dents Kotoko’s chances of defending their league title   –last_img read more

admin

Los Angeles Dodgers pick wrong time for photo op with Mexico’s President Enrique Peña Nieto

first_img Newsroom GuidelinesNews TipsContact UsReport an Error People are speaking out on social media against the Los Angeles Dodgers’ decision to have Adrian Gonzalez present Mexico president Enrique Peña Nieto with a customized jersey this week.The gift and photo op come while families wait for closure and others stage protests and hold vigils following 43 teaching students going missing after a confrontation with police in late September. The police have cartel ties and the students are presumed dead.If you have trouble viewing this on mobile, click herelast_img

admin