Curis Doses First Patient in Phase 1 Study of CA-4948 in Combination with Ibrutinib…

first_img LEXINGTON, Mass., Feb. 9, 2021 /PRNewswire/ — Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, today announced that the first patient has been dosed in its Phase 1 trial evaluating CA-4948, a novel, small molecule IRAK4 kinase inhibitor, in combination with ibrutinib, a BTK inhibitor, in patients with relapsed or refractory (R/R) hematologic malignancies. “In dosing the first patient in this Phase 1 study evaluating CA-4948 and ibrutinib, we are taking a highly anticipated step forward in bringing a potent oral therapeutic regimen to patients with relapsed or refractory hematologic malignancies,” said James Dentzer, President and Chief Executive Officer of Curis. “BTK inhibitors are an approved category of therapies for patients with various lymphatic cancers yet they only target one of the two main pathways activating NF-κB in B-cell malignancies. CA-4948 targets the other main NF-κB-activating pathway by shutting down signaling through the Myddosome. We have shown highly encouraging increased tumor-reducing activity when combining both covalent and non-covalent BTK inhibitors with CA-4948 in preclinical models.” Mr. Dentzer continued, “We observed single-agent activity in the non-Hodgkin’s lymphoma (NHL) monotherapy study, with the majority of patients treated at 300mg twice daily experiencing at least some reduction in tumor volume. We coordinated with our trial partners to amend the protocol of our existing study to include combination therapy starting at a previously demonstrated therapeutic dose. This will allow us to leverage the clinical sites and staff currently active in our monotherapy study and should save significant time and resources as we advance through the clinic.” “Given the profile CA-4948 has demonstrated in existing studies, it is a promising candidate for combination with a proven BTK inhibitor such as ibrutinib,” said Dr. Erel Joffe, M.D., Assistant Attending with the Lymphoma Service at Memorial Sloan Ketting Cancer Center and a lead investigator on the study. “We believe there may be important synergies given that IRAK4 controls the critical TLR pathway that is parallel and complementary to the BTK pathway and that both of these pathways are primary and independent oncogenic activators of NF-κB in lymphoma and leukemia. Effective dual targeting of both independent pathways that drive excessive B-cell proliferation via NF-κB could potentially provide significantly improved outcomes over either treatment in a monotherapy setting.” About the CA-4948+ibrutinib Phase 1 Combination Study The Phase 1 trial is a two-part, multicenter, open-label, dose escalation and expansion study designed to evaluate the safety, pharmacokinetics, pharmacodynamics, clinical activity, and biomarker correlations of CA-4948 and ibrutinib patients with relapsed or refractory hematologic malignancies. Part 1 of the study is a dose escalation using a 3+3 design. Approximately 18 patients will be enrolled in Part 1 and will receive a starting dose of 200mg CA-4948 BID with subsequent escalation to 300mg BID, both of which have been observed to be safe and effective in the NHL monotherapy study, combined with ibrutinib doses appropriate for their respective NHL subtype. The primary endpoints of Part 1 will be safety and tolerability, maximum tolerated dose, and the recommended Phase 2 dose. Secondary objectives will be pharmacokinetics and preliminary efficacy. Exploratory objectives will include biomarker correlations, such as MYD88-L265P mutations and IRAK4 pathway and NFκB inhibition. Part 2 of the study will enroll patients across an expansion basket of four cohorts: marginal zone lymphoma (MZL), ABC-DLBCL, primary central nervous system lymphoma (PCNSL), and NHL with adaptive ibrutinib resistance. An interim futility analysis will be conducted after approximately 15-20 patients are enrolled in each cohort. Primary endpoints of Part 2 will be complete response or objective response rate and duration of response compared to historical controls. Secondary objectives will be safety and tolerability, progression-free survival, and population PK sampling for CA-4948. Exploratory objectives will include response correlation with biomarkers including MYD88-L265P or other genetic mutations, gene expressions, cell of origin, IRAK4 signaling, and resistance. About Curis, Inc. Curis is a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer. In 2015, Curis entered into a collaboration with Aurigene in the areas of immuno-oncology and precision oncology. As part of this collaboration, Curis has exclusive licenses to oral small molecule antagonists of immune checkpoints including the VISTA/PDL1 antagonist CA-170, and the TIM3/PDL1 antagonist CA-327, as well as the IRAK4 kinase inhibitor, CA-4948. CA-4948 is currently undergoing testing in a Phase 1 in patients with non-Hodgkin’s lymphoma both as a monotherapy and in combination with BTK inhibitor ibrutinib. Curis is also evaluating CA-4948 in a Phase 1 trial in patients with acute myeloid leukemia and myelodysplastic syndromes. In addition, Curis is engaged in a collaboration with ImmuNext for development of CI-8993, a monoclonal anti-VISTA antibody, which is currently undergoing testing in a Phase 1a/1b trial in patients with solid tumors. Curis is also party to a collaboration with Genentech, a member of the Roche Group, under which Genentech and Roche are commercializing Erivedge® for the treatment of advanced basal cell carcinoma. For more information, visit Curis’ website at www.curis.com. Forward-Looking Statements: This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995, including, without limitation, statements regarding any expectations of the potential for the Company’s proprietary drug candidate CA-4948, including the potential developments and benefits of CA-4948 in combination with BTK inhibitors such as ibrutinib, statements with respect to the timing of the Company’s studies, including enrollment and reporting of data, and the Company’s ability to advance and broaden its clinical programs. Forward-looking statements may contain the words “believes,” “expects,” “anticipates,” “plans,” “intends,” “seeks,” “estimates,” “assumes,” “will,” “may,” “could” or similar expressions. These forward-looking statements are not guarantees of future performance and involve risks, uncertainties, assumptions and other important factors that may cause actual results to be materially different from those indicated by such forward-looking statements. For example, Curis may experience adverse results, delays and/or failures in its drug development programs and may not be able to successfully advance the development of its drug candidates in the time frames it projects, if at all. Curis’s drug candidates may cause unexpected toxicities, fail to demonstrate sufficient safety and efficacy in clinical studies and/or may never achieve the requisite regulatory approvals needed for commercialization. Favorable results seen in preclinical studies and early clinical trials of Curis’s drug candidates may not be replicated in later trials. There can be no guarantee that the collaboration agreements with Aurigene and ImmuNext will continue for their full terms, that Curis or its collaborators will each maintain the financial and other resources necessary to continue financing its portion of the research, development and commercialization costs, or that the parties will successfully discover, develop or commercialize drug candidates under the collaboration. Regulatory authorities may determine to delay or restrict Genentech’s and/or Roche’s ability to continue to develop or commercialize Erivedge in BCC. Erivedge may not demonstrate sufficient or any activity to merit its further development in disease indications other than BCC. Competing drugs may be developed that are superior to Erivedge. In connection with its agreement with Oberland Capital, Curis faces risks relating to the transfer and encumbrance of certain royalty and royalty-related payments on commercial sales of Erivedge, including the risk that, in the event of a default by Curis or its wholly-owned subsidiary, Curis could lose all retained rights to future royalty and royalty-related payments, Curis could be required to repurchase such future royalty and royalty-related payments at a price that is a multiple of the payments it has received, and its ability to enter into future arrangements may be inhibited, all of which could have a material adverse effect on its business, financial condition and stock price. Curis will require substantial additional capital to fund its business. If it is not able to obtain sufficient funding, it will be forced to delay, reduce in scope or eliminate some of its research and development programs, including related clinical trials and operating expenses, potentially delaying the time to market for, or preventing the marketing of, any of its product candidates, which could adversely affect its business prospects and its ability to continue operations, and would have a negative impact on its financial condition and its ability to pursue its business strategies. Curis faces substantial competition. Curis also faces risks relating to potential adverse decisions made by the FDA and other regulatory authorities, investigational review boards, and publication review bodies. Curis may not obtain or maintain necessary patent protection and could become involved in expensive and time-consuming patent litigation and interference proceedings. Unstable market and economic conditions, natural disasters, public health crises, political crises and other events outside of Curis’s control could significantly disrupt its operations or the operations of third parties on which Curis depends, and could adversely impact Curis’s operating results and its ability to raise capital. For example, the COVID-19 pandemic may result in closures of third-party facilities, impact enrollment in clinical trials or impact sales of Erivedge by Genentech and/or Roche. The extent to which the COVID-19 pandemic may impact Curis’s business or operating results is uncertain. Other important factors that may cause or contribute to actual results being materially different from those indicated by forward-looking statements include the factors set forth under the caption “Risk Factors” in our most recent Form 10-K and Form 10-Q and the factors that are discussed in other filings that we periodically make with the Securities and Exchange Commission (“SEC”). In addition, any forward-looking statements represent the views of Curis only as of today and should not be relied upon as representing Curis’s views as of any subsequent date. Curis disclaims any intention or obligation to update any of the forward-looking statements after the date of this press release whether as a result of new information, future events or otherwise, except as may be required by law. View original content to download multimedia: http://www.prnewswire.com/news-releases/curis-doses-first-patient-in-phase-1-study-of-ca-4948-in-combination-with-ibrutinib-in-patients-with-relapsed-or-refractory-hematologic-malignancies-301224625.html SOURCE Curis, Inc. Local NewsBusiness WhatsApp Curis Doses First Patient in Phase 1 Study of CA-4948 in Combination with Ibrutinib in Patients with Relapsed or Refractory Hematologic Malignancies Facebook Pinterest Pinterest By Digital AIM Web Support – February 9, 2021 center_img TAGS  Twitter Twitter WhatsApp Facebook Previous articleDaniel Kagan Promoted to President at Scientist.comNext articleArtisanal Self-Care Subscription Box Brand Little Slacks Announces Valentine’s Day Giveaway Digital AIM Web Supportlast_img read more

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The study of global atmospheric pollution in Antarctica

first_imgWaste products from man’s activities, released into the environment, distribute themselves between the atmosphere, the land, the sea and, through these, to the biota. There is a constant interchange of material between reservoirs leading, it is thought, to an ultimate sinking of trace materials into the depths of the ocean where they slowly accumulate on the ocean bed and are removed from the circulation system. Substances released into the air can rise into the upper atmosphere and spread all over the world before they finally sediment into the lower atmosphere and suffer washout. The overall lifetime of a particular pollutant is determined by its concentration in each reservoir and by its rate of transfer between different pairs of reservoirs. A major goal for scientists is to achieve a quantitative description of this process for the major pollutants so that in the future it may be possible to predict the changing concentrations with time, in each reservoir, of a potentially harmful pollutant of known input rate into the environment.last_img read more

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Press release: UK support for Ukraine reform

first_imgFurther information Follow the Foreign Secretary on Twitter @BorisJohnson and Facebook Follow the Foreign Office on Twitter @foreignoffice and Facebook Follow the Foreign Office on Instagram, YouTube and LinkedIn Media enquiries Boris Johnson discussed the contribution at the Ukraine Reform Conference – a year after the UK hosted the inaugural summit in London.Since then, Ukraine has made great strides in tackling corruption and improving transparency across Ukrainian institutions, and important progress on decentralisation and healthcare reform.The Foreign Secretary Boris Johnson said:“With Russia continuing its efforts to destabilise Ukraine, and the occupation of Crimea ongoing, Britain must help to lead the way on ensuring Ukraine has a bright, stable and prosperous future“That’s why we continue to provide support, which will help Ukraine to build on the progress it has made since 2014 and on key reforms since the inaugural London Reform Conference last year“We do all this because it is essential for Ukraine’s future security and prosperity, and because it is essential for upholding our European values, our security and our prosperity.”The funding will provide practical support to strengthen Ukraine’s sovereignty and resilience, and ensure the reform momentum continues. It includes help for projects in Ukraine to bolster further reform across the country’s institutions, eliminate corruption, and increase independent oversight of state organisations.The UK is already doing pioneering work in Ukraine to help tackle Russian disinformation. This includes support to Ukraine’s public broadcaster, a project to help Ukrainian schools to build resilience against disinformation, and funding for an NGO network across Europe to debunk fake media stories.The Foreign Secretary also held talks with Danish foreign minister Anders Samuelsen while in Copenhagen.NOTES:Funding includes: For journalists £13.4 million on conflict, security and stability projects to bolster Ukrainian defence reform, promote peace-building, eliminate corruption and increase civilian oversight £11 million to support reform in Ukraine through the Good Governance Fund with a wide range of programmes to help Ukraine drive forward governance, economic and political reform. Through this, we are supporting key institutions like the Business Ombudsman and the National Anti-Corruption Bureau. £6 million in humanitarian aid. £5 million this year to help Ukraine counter Russian disinformation. Email [email protected]last_img read more

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Premier League final day TV schedule, fixtures, channels and live streams

first_imgAdvertisement Metro Sport ReporterFriday 24 Jul 2020 9:37 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link Comment Premier League final day TV schedule, fixtures, channels and live streamscenter_img Advertisement Manchester United have a huge final day of the season against Leicester City (Picture: AFP via Getty Images)Sunday 26 July sees this unique Premier League season come to an end, with all 20 teams in action and plenty still to play for.All the matches kick-off at 4pm on Sunday and while the title has long been wrapped up by Liverpool, there are European places and relegation spots to confirm.The Reds and Manchester City have secured the top two places in the table, but Manchester United, Chelsea and Leicester are fighting over the next two, with the Red Devils and the Foxes facing each other.If United avoid defeat they will finish in the top four, but Leicester will be pushing hard as they look to climb above them, currently two places and one point behind them in fifth. AdvertisementAdvertisementADVERTISEMENTChelsea sit between the sides, level on points with United, but with an inferior goal difference to Leicester. If the Blues lose to Wolves, a draw between United and Leicester would see those two teams take top four spots.Relegation is tight, with Aston Villa 17th on 34 points and Watford one place behind them but with the same points and just one worse off on goal difference.It looks like a two-way scrap to stay up, but if both lose on Sunday and Bournemouth win, the Cherries will overtake both.Tension awaits.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityWhat TV channels the final day fixtures on?Arsenal vs Watford – Sky Sports Premier LeagueBurnley vs Brighton – Sky Sports ArenaChelsea vs Wolves – Sky Sports FootballCrystal Palace vs Spurs – Sky Sports ActionEverton vs Bournemouth – Sky Sports GolfLeicester vs Man Utd – Sky Sports Main EventMan City vs Norwich – Sky Sports Pick/Sky OneNewcastle vs Liverpool – BT Sport 2Southampton vs Sheffield United – Sky Sports MixWest Ham vs Aston Villa – BT Sport 1All games kick-off at 4pmSky Sports subscribers can stream their games on the Sky Sports app or on Sky Go, while non subscribers can buy a Sky Sports Pass from Now TV.To stream BT Sport matches, you will need to subscribe to a BT Sport package.The Man City vs Norwich game is available on free-to-air TV.MORE: Premier League dates set for 2020/21 seasonMORE: Liverpool? Man City? Chelsea? Man Utd? Ray Parlour predicts who will win Premier League next seasonFollow Metro Sport across our social channels, on Facebook, Twitter and Instagram.For more stories like this, check our sport page.last_img read more

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Brandon McCarthy struggles, Dodgers streak ends at 11

first_img Newsroom GuidelinesNews TipsContact UsReport an Error LOS ANGELES >> The Dodgers’ streak of 31 wins in 36 games, including 11 in a row before Thursday, was fraught with so little adversity that comparisons to other Major League Baseball teams began to fall short. A reporter asked manager Dave Roberts to compare his team to the most recent NBA champion, the Golden State Warriors. Flattered, Roberts was quick to point out the Dodgers have not won a World Series for all their recent success.Flattery comes with the territory when making a difficult thing look easy. While the Dodgers ascended into rare company — since June, they’ve been on pace for the best 162-game record ever by a National League team — this was never Brandon McCarthy’s territory. McCarthy’s latest start lasted a mere four innings Thursday — not quite his shortest this season, but long enough for the Atlanta Braves to score six runs en route to a 6-3 victory at Dodger Stadium. The Dodgers never led the Braves at any point, a first since their previous loss on July 2.McCarthy has gone to the disabled list twice in his first full season back from Tommy John surgery. His right knee was bothering him long before it caused him to miss a start earlier this month. The 34-year-old right-hander recently revealed that he’s been dealing with finger blisters after every start for the first time in his career.Throw in a much scarier mental hiccup — an acute recurrence of the yips June 25, which mercifully did not bleed into his next outing — and McCarthy’s last month has scarcely mirrored his team’s. His earned-run average has risen from 2.87 to 3.84 since June 20.center_img The Braves scored two runs against McCarthy in the first inning Thursday and never looked back.“Command the last few (games), things had gotten really sloppy,” McCarthy said. “Mechanics have been really shoddy and this week we really went to work trying to clean it up after Miami. We got it back to a place where I feel, oddly enough, I feel happy with what happened (Thursday) other than the actual results.”McCarthy downplayed the impact of his finger blister. It came to Roberts’ attention in the fourth inning, when Atlanta tacked on three more runs to take a 6-1 lead, but it was not the reason Roberts pulled McCarthy after four innings.Still, the blister could quickly turn into an excuse for the Dodgers to send McCarthy to the disabled list. They have five healthy starters. Hyun-Jin Ryu has thrown two simulated games since going on the disabled list with a bruised foot, and was already scheduled to rejoin the rotation next week.Earlier this year the Dodgers sent Rich Hill to the disabled list for a month with a finger blister. Hill effectively started his season over, allowing a callous to form on the affected finger. Roberts said that’s an option now for McCarthy.“We’ll talk to the trainers, talk to Brandon and see how (the blister) responds tomorrow, how it looks tomorrow,” Roberts said. “Most importantly we have to make sure he’s right. We have some time for that.”Any trip to the DL now would come at a more precarious time in the baseball calendar. The non-waiver trade deadline is July 31. The Dodgers have baseball’s best record (66-30) and less urgency to upgrade their roster than any contending team. But the downward trend is coming at a bad time for McCarthy, the only right-hander to start a game for the Dodgers this year beyond Kenta Maeda.Atlanta wasted little time asserting itself Thursday. McCarthy allowed four hits in the first inning, including a ground-rule double by Matt Adams to provide a 2-0 lead.The Dodgers got a run back in the bottom of the first inning on a Corey Seager double and an RBI single by Cody Bellinger.Freddie Freeman drove in Brandon Phillips with the Braves’ third run in the third inning. Atlanta chased McCarthy by scoring three runs in the fourth, topped by a two-run Kurt Suzuki home run.Yasmani Grandal hit a two-run home run off Braves starter Mike Foltynewicz, his 13th homer this season, in the bottom of the sixth inning. Grandal also leaped to snag a throw from left fielder Chris Taylor and tag out Adams at home plate in the eighth inning.Earlier in the day, Grandal endured a root canal.“I just pretty much had my mind set on ‘I know it’s going to suck but you’ve just got to play through it and try to win a game today’,” he said. “The last three or four days were pretty bad.”Grandal’s performance was a rare bright spot. The Dodgers collected seven hits and three walks, but went 2 for 12 with runners in scoring position.Braves second baseman Brandon Phillips exited the game with tightness in his right hamstring. He is day to day.last_img read more

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Peter Crouch named the only player ever to scare him

first_img Muscat never pulled out of challenges, picking up 123 yellow cards in his career 4 Crouch was left terrified by the Aussie hard man 4 Stoke City forward Peter Crouch revealed the only footballer to ever truly scare him was Kevin Muscat.Veteran striker Crouch has enjoyed a lengthy career at the highest level, winning 42 caps for England, representing 11 different clubs – and playing in a Champions League final for Liverpool. Speaking on his show, ‘That Peter Crouch Podcast’, the 6ft 7ins striker said: “Kevin Muscat scared me.“You know people would say ‘I’m going to break your legs’ – when he would say it, you genuinely believed him.” Crouch infamously clashed with Gennaro Gattuso in 2012 center_img Muscat tackles Nigel Reo-Coker while captaining Millwall in a clash with West Ham 4 4 Along the way, the 37-year-old has experienced his fair share of highs and lows and met some unsavoury characters.However, they all pale in comparison to legendary hard man Muscat, who counts Rangers, Wolves and Millwall among his former clubs. The Australian defender was once known as ‘the most hated man in football’ after gaining a reputation as a brutal enforcer on the pitch.Former Charlton Athletic midfielder Matty Holmes was awarded £250,000 by the High Court in 2004 after a malicious challenge by Muscat left the player requiring skin grafts and a metal bolt inserted in his ankle after the clash.Other incidents included being branded a ‘lowlife’ by Arsenal great Ian Wright, stamping on Danny Webber’s head, elbowing Gold Coast United midfielder Jason Culina, threatening to break Ashley Young’s legs while he was a young winger at Watford, and committing was has been branded one of the worst tackles in football history on Adrian Zahra.He ended his professional career with 123 yellow cards and 12 red cards, and in 2013 was voted ‘football’s dirtiest ever player’ by Spanish outlet El Gol Digital.last_img read more

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Lady Spartans finish season with loss; Cardinals remain perfect with win over Oroville

first_imgRed Bluff >> The Red Bluff Lady Spartans wrapped up the regular season Thursday night against the league-leading Pleasant Valley Vikings and fell 69-36 in a physical game.The Vikings dominated the first period, taking a 14-3 lead by the buzzer, but Kylee Kitchell and Maggie Winning found the net in the second to keep the deficit at 11 by the half, 25-14.The Spartans pulled within 10 in the third but that’s as close as they would get, with the Vikings leading 44-26 after three and going on a …last_img

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Nestle joins ‘Adopt-a-School’ campaign

first_imgMpumelelo is the first of many schools that Nestle will adopt and assist. The company’s communications director, Ravi Pillay, explained: “The plan is that where Nestle has an operation, the model will be implemented. “Education,” he said, “is everyone’s business”. She paid tribute to the school’s principal, WB Maphanga, and his staff for the success, saying they made all the difference. The success has been achieved despite the school facing some tough challenges, such as having only eight classes for 560 pupils, most of whom come from indigent families, whose parents are mostly unemployed and have no formal education. A culture of learning Established in 2007, Mpumelelo High School has been a tremendous success – the name in fact means “success” – and a source of pride to people in the area. Nestle South Africa has become one of the first corporates in the country to respond to the recently launched “Adopt-a-School” campaign. The company “adopted” Mpumelelo High School, near Estcourt in KwaZulu-Natal, at a ceremony on Tuesday. Nestle South Africa has now joined the likes of banking group Absa, financial services group Alexander Forbes and the Industrial Development Corporation (IDC) in becoming part of the movement with its own “Adopt-A-School” initiative. Addressing the pupils, parents and guests in attendance, Mchunu added: “At my age, there are not many things that inspire me, but today I am inspired by this school.” Linda, a parent, told SAinfo afterwards that she was proud to have four children in the school. One of her children had failed grade 10 at the local high school in Estcourt, but after moving to Mpumelelo had passed with flying colours. Now, with Nestle on board, that is about to change, and the school is about to be blessed with some invaluable educational aids; Nestle will build a science laboratory, a computer lab, a school library, provide water, and also install a sports field, which the pupils have not yet been able to enjoy. The company said its Adopt-A-School intitiative was in line with Nestle’s worldwide “creating shared values” business strategy, which states that for a business to be successful in the long term, it has to create value for the communities in which it operates. Maphanga, in his address, said the school’s excellent results had come about because a culture of learning had been instilled. “The key to resolving government’s challenges is to create meaningful partnerships with the private sector in community development projects such as this Adopt-A-School initiative,” KwaZulu-Natal MEC for Education Senzo Mchunu said at Tuesday’s launch. 2 November 2011 In the mornings, the pupils have to walk to school very early, carrying water with them, because there is no water supply at the school. The first of many ‘Creating meaningful partnerships’ Nestle SA managing director Sullivan O’Carroll said that Nestle had brought in its partners, those companies it does business with, to help bring about the big contribution the company was making to Mpumelelo High School. The food and drinks maker employs 420 people at its coffee and beverages factory in Estcourt, and thus a nearby school was chosen as the first beneficiary of the initiative. The Accord on Basic Education and Partnerships with Schools campaign, launched in October by Brand South Africa, the Department of Basic Education and the National Economic Development and Labour Council, encourages businesses to “adopt” schools and donate educational facilities to them. Education, he said, was about giving people an opportunity to compete in the world. “It may vary in terms of detail, but the primary objectives will be the same – to ensure skills development and enhancing quality of life. But most importantly, it is our way of contributing towards rural development.” Tough challenges It is this kind of dedication that led Nestle to choose to assist Mpumelelo. More success is surely on its way, yet life as the staff, pupils and parents at the school know it is about to become a lot better, thanks to Nestle’s decision to “Play its Part” in making this happen. A dedicated teacher, Maphanga arrives at school at a quarter-to-six every morning. Upon arriving, he checks whether any overnight rain has been caught to boost water levels. If not, he fetches water himself. In its first year, it produced a 75 percent pass rate. The following year that figure was up to 85 percent. In 2009 and 2010 that mark was a perfect 100 percent. Would you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more

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Enabling The Mobile-First Enterprise

first_imgGuest author Jesus Rodriguez is the CEO and co-founder of KidoZen.It has taken more than five years, but the first phase of integrating mobile into enterprises is almost over. Enterprise mobility is evolving. The first generation of enterprise mobile solutions focused on the management of mobile devices (MDM), enabling traditional email applications and the occasional custom mobile app. It is time to take the next step. A new generation of mobile technologies is helping enterprises to reimagine entire business processes from a mobile-centric standpoint. This movement is starting to be known in the industry as “the mobile-first enterprise.” This is an attractive concept for most organizations. But, building the mobile-first enterprise is far from an easy endeavor. Based on our experience, this type of transformational movement is a long-term process that requires various foundational components from both the technological and organizational standpoint.What are the elements that can help to enable the mobile-first enterprise? Some of the ideas listed below might help.BYOD Is An Enabler, Not The End GoalThe “bring your own device” movement has become a catalyst to the evolution of enterprise mobility solutions. Empowering employees to use their own tablets and smartphones for work-related activities has become a core characteristic of the modern enterprise.  Related Posts The Rise and Rise of Mobile Payment Technology However, most organizations are still building the required security, management and compliance infrastructure to enable a BYOD environment. To evolve, organizations must realize that BYOD by itself is just a starting point to build the mobile-first enterprise. Not the end result. Enabling mobile-first enterprise applications and business processes that access corporate data from personal devices in a secure and efficient manner is the true end goal of the mobile-first enterprise. Beyond MDMMobile Device Management (MDM) has been at the center of the first generation of enterprise mobile. The ability to manage and secure smartphones/tablets has been seen as a key element of any enterprise mobile infrastructure. Consequently, in recent years, the market is experiencing an explosion on the number of MDM technologies claiming to be the silver bullet to enable an enterprise mobile infrastructure.Managing connected devices is not enough to implement mobile-first enterprise applications. Expanding beyond MDM and focusing on managing the enterprise mobile applications and the corresponding business data in your infrastructure are, arguably, more relevant capabilities to enable the mobile-first enterprise. Contextualizing and Mobilizing Business DataOne of the holy grails of enterprise mobile infrastructure is to enable mobile applications to leverage data hosted in corporate business systems. It may be conceptually trivial, but the process of mobilizing business data can be extremely challenging.In order to enable a mobile-first enterprise experience, organizations need to build the infrastructure to contextualize business data so that it can be effectively consumed on enterprise mobile applications. While technologically challenging, building the infrastructure to effectively mobilize data from corporate systems can drastically simplify the experience of incrementally building enterprise mobile applications. Mobilizing Existing Business ProcessesSome of the most successful organizations are the ones that have been able to redefine existing business processes using a mobile-first approach. In this model, traditional business capabilities – enabled via a desktop experience – will be simplified and redesigned for smartphones or tablets in order to provide an optimal productivity experience. Creating Mobile-First Business ProcessesIn addition, enterprises are starting to create new business processes to enable new business capabilities using a mobile-first paradigm. Mobile point-of-sale (POS) or mobile customer relationship management (CRM) systems are some of the best examples of mobile-first business processes being enabled in today’s enterprises. This type of mobile-centric business capabilities is a key element in the DNA of the mobile-first enterprise and helps organizations achieve greater differentiation and agility in the current mobile economy. Leverage Mobile-First Business AppsThe previous sections have highlighted the importance of building the infrastructure to implement new enterprise mobile apps as an essential element to enable the mobile-first enterprise. Equally important, is for organizations to invest in the infrastructure required to adopt domain-specific mobile business apps available in the marketplace. As the adoption of mobile technologies increases in the enterprise, we are starting to witness a new generation of mobile-first business apps that are redefining both horizontal and vertical business capabilities. Enabling the infrastructure to adopt those new mobile business apps in an efficient, secure approach tailored to your enterprise can improve the journey to the mobile-first enterprise.Images courtesy of Shutterstock. jesus rodriguez What it Takes to Build a Highly Secure FinTech … Why IoT Apps are Eating Device Interfaces Role of Mobile App Analytics In-App Engagement Tags:#BYOD#Consumerization of the Enterprise#smartphones last_img read more

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India Today Youth Summit 2011: Welcome address by Aroon Purie

first_imgWelcome address by Aroon Purie, Chairman and Editor in Chief, India Today Group at the Mind Rocks India Today Youth Summit 2011:Welcome everyone to India Today’s Second Youth Summit. A lot has changed since we last met. Last year, the mood was one of infectious optimism, of a country that had withstood a global recession. Then, one by one, the dominoes started to fall. The Commonwealth Games scam embarrassed us in front of the world. The 2G scam blew the lid off the prized telecom revolution.It was as if nothing was sacrosanct. The Army used land allotted for war widows for its own housing. One man evaded taxes worth Rs 50,000 crore. Swiss bankers started whispering about India’s best kept secret: the black money of its rich and powerful stashed away in Swiss banks.Yet, equally suddenly, there was hope, but of a different kind. That politics as we know it could change forever. That the power of the people could prevail over the power of those who had forgotten how to listen to them. That corruption may be a global phenomenon but it could have a very Indian solution.Eighteen-year-olds may have become voters in 1989 but 2011 will be remembered as the year they became citizens. It happened because of people like you.The extraordinary events of the last three months have changed the way young people are perceived. They, we were told, was the I-Me-Myself generation. I see now that they may have become the We generation.We were told modern communication tools like e-mail, SMS or Facebook would divide people. They ended up uniting your generation across cities, classes and communities.advertisementWe were told globalization would make our youth too westernized. The tricolour has instead become your favourite accessory.We were told young people were not interested in politics. But, one by one, as you converged on Ramlila Maidan in Delhi or Azad Maidan in Mumbai or Freedom Park in Banglore, with candles, slogans, and change in your hearts, you proved us and them wrong.Like a generation before you did in 1974, you were asking for accountability.The students’ revolution of 1974 threw up many of our present-day political stalwarts, from Lalu Prasad Yadav to Sushil Modi. Who knows how many of you who are Anna revolutionaries will go into politics, even though a new opinion poll we are carrying in the latest issue of India Today shows a tremendous anger against all politicians.In 1974, a man very similar to Anna Hazare, Jayaprakash Narayan, said almost the same things being said now. He too wanted to curb corruption. He too wanted to check the erosion of democracy. He too wanted changes in the electoral laws so that a “poor man’s democracy could work more honestly in a poor country”.Much has changed since then. Much has also remained the same.Two-thirds of India is under 35 – like most of you sitting in this hall. The numbers are huge. 459 million Indians are between 13 and 35. Of these, 333 million are literate.Till now, you were seen as a market. This year you proved, as you rallied behind a 74-year-old man from a hitherto obscure village in Maharashtra, that you were a democracy.As a 200-million strong voting force of 18-35 year olds in the 2009 elections, you were always seen as a swing factor. This time you proved the swing could well be a tsunami.All of you realise how you can change the rules of the game. You have every opportunity to change it further.  By 2020, just a decade from now, the average Indian will be 29 and we will have the unique distinction of being one of the youngest nations in the world. This means we would have the energy, dynamism and confidence which comes with youth.As India integrates further into the world economy, you will prove your worth on an international scale. We are already the second largest reservoir of skilled labour in the world. We produce an astounding two million English-speaking graduates, 15,000 law graduates, and 9,000 PhDs every year. And every year, the existing pool of over two million engineering graduates increases by nearly 300,000.The world awaits your ideas, your effort and your attention.When I was growing up, our horizons were limited because of our controlled, closed economy and our bullock-cart rate of growth. Today, India’s growth rate is the envy of most nations. And, far from being insulated, we have an open economy plugged into the world.Our summit this year shows us the power of great ideas. The summit is called Mind Rocks and, quite appropriately, each of our speakers today is a rock star in their own field.advertisementOur inaugural speaker, Kumar Mangalam Birla, has taken his company to new heights globally, with an empire spanning steel and cement to financial services.Chetan Bhagat is a writer who embodies the new, young, successful Indian – as much at ease in a Deutsche Bank office in Singapore as he is sitting in a sweaty set in Mumbai’s Film City.Abhinav Bindra is a thoughtful young man who used the gift of science to shoot for excellence in his sport, getting India its first individual Olympic gold medal.World Champions Yuvraj Singh and Gautam Gambhir show us what the fighting spirit is all about, while Ranbir Kapoor’s journey so far tells us that a famous surname is no deterrent to hard work.Innovative filmmaker Kiran Rao, brilliant artist Subodh Gupta, politician Kalikesh Singh Deo and Internet entrepreneur Divya Narendra will tell you: that a career is more than just a job.Zarina Mehta will tell you what goes into entertaining you. And our last speaker today, Kiran Bedi, will tell us what made her quit the police force and become a social activist who played a key role in the recent anti-corruption movement.This is a great time to be young in India. You are in the right place at the right time. The possibilities are immense and the India of the future is in your hands. To borrow a phrase, “You must be the change you want to be”.I am confident that Mind Rocks, with its mix of fun, music, intellectual stimulation and lots of career advice, will give you some pointers.last_img read more

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