Nerve Traffic Cop Identified

first_imgWhat makes signals go in one direction in neurons?  It’s important, because a reflex signal from a bump on your knee needs to go in the direction of the controlling muscle and on to the brain, not any which way.  Is there some kind of traffic cop that directs the placement of “one way” signs in nerve cells?  Indeed there is.  According to a press release from the University of Georgia, it’s the enzyme MEC-17.    Researchers were not attempting to cure a disease or derive an application from finding this out; they just wanted to know how it works.  How do neurons know which direction to send the signals?  It appears that MEC-17, which they studied in roundworms, zebrafish and human cancer cells, is responsible for placing the traffic signs, called acetylation marks, on the cellular highways made of microtubules.  The paths with lots of these marks are on the sending end, and the paths with few of them are on the receiving end.  When the marks are not set properly, bad things happen: zebrafish develop neuromuscular defects, and humans are subject to debilitating neural diseases like Parkinson’s, Alzheimer’s and Huntington’s.  This discovery may lead to new treatment strategies by enhancing or inhibiting the action of MEC-17.    By noticing that MEC-17 works identically in animals as diverse as roundworms, fish and humans, the researchers deduced that “this microtubule acetylation process using MEC-17 is an evolutionarily conserved function.”  Conserved means un-evolved.Saying evolutionarily conserved is like saying “aimlessly straight.”  It’s a meaningless phrase we should not be duped into thinking signifies anything logical.  This discovery emphasizes once again that things do not just happen; specific parts that are functionally exquisite are necessary for function.  One question the research team appeared to overlook, though, is what controls MEC-17?  If this enzyme puts up the signs, who is the foreman?  We are certainly not consciously controlling much of this in our bodies.  Most of it happens without our knowledge.  It’s like the infinite regress question: who watches the watchers?  The hierarchy of design must eventually stop at a Designer who is omniscient and omnipotent.(Visited 7 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

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China & Africa: ‘win-win situation’

first_img23 June 2006Chinese Premier Wen Jiabao has reassured African states that China’s generosity towards poor countries has no hidden agendas and comes with “no strings attached”.“Our cooperation with African countries is transparent, open and inclusive and we will always promote a win-win situation,” he said at the opening of the China-South Africa Business Cooperation Forum in Cape Town on Thursday, during his two-day visit to South Africa.“China has endeavored to provide assistance without any political strings attached to our brothers and sisters in Africa to the best of our ability,” he said.Wen cited the almost one thousand social and economic projects China had initiated in and for the benefit of African countries over the years as evidence that his country had no negative intentions.“We respect the social system and development strategy pursued by African countries in light of their particular national conditions. We do not seek to export our own values and developmental models to Africa.”With Africa calling for equitable representation at the UN Security Council, Wen said his country would not hesitate to lend its support to the positions adopted by the continent internationally and domestically.“We will continue to speak out for the interests of Africa at international forums and support African countries in their efforts to safeguard sovereignty, independence and promote regional peace and stability,” he said.Also at the forum, Deputy President Mlambo-Ngcuka said China and South Africa had a lot in common, and the two countries had much to gain by working together.“Both countries are currently under pressure to deliver on Millennium Development goals, we both face energy challenges and our economies are characterised by the huge gap between the first and second economy,” she said.She said working together would allow the two countries to learn from each other’s experiences.Thursday’s forum is likely to result in more investment between China and South Africa in the areas of infrastructure development, tourism and minerals beneficiation. Both countries are currently exploring pebble-bed nuclear reactor technology to increase energy outputs.“This is one of the areas where we will be cooperating in,” Mlambo-Ngcuka confirmed.Source: BuaNewslast_img read more

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Enabling The Mobile-First Enterprise

first_imgGuest author Jesus Rodriguez is the CEO and co-founder of KidoZen.It has taken more than five years, but the first phase of integrating mobile into enterprises is almost over. Enterprise mobility is evolving. The first generation of enterprise mobile solutions focused on the management of mobile devices (MDM), enabling traditional email applications and the occasional custom mobile app. It is time to take the next step. A new generation of mobile technologies is helping enterprises to reimagine entire business processes from a mobile-centric standpoint. This movement is starting to be known in the industry as “the mobile-first enterprise.” This is an attractive concept for most organizations. But, building the mobile-first enterprise is far from an easy endeavor. Based on our experience, this type of transformational movement is a long-term process that requires various foundational components from both the technological and organizational standpoint.What are the elements that can help to enable the mobile-first enterprise? Some of the ideas listed below might help.BYOD Is An Enabler, Not The End GoalThe “bring your own device” movement has become a catalyst to the evolution of enterprise mobility solutions. Empowering employees to use their own tablets and smartphones for work-related activities has become a core characteristic of the modern enterprise.  Related Posts The Rise and Rise of Mobile Payment Technology However, most organizations are still building the required security, management and compliance infrastructure to enable a BYOD environment. To evolve, organizations must realize that BYOD by itself is just a starting point to build the mobile-first enterprise. Not the end result. Enabling mobile-first enterprise applications and business processes that access corporate data from personal devices in a secure and efficient manner is the true end goal of the mobile-first enterprise. Beyond MDMMobile Device Management (MDM) has been at the center of the first generation of enterprise mobile. The ability to manage and secure smartphones/tablets has been seen as a key element of any enterprise mobile infrastructure. Consequently, in recent years, the market is experiencing an explosion on the number of MDM technologies claiming to be the silver bullet to enable an enterprise mobile infrastructure.Managing connected devices is not enough to implement mobile-first enterprise applications. Expanding beyond MDM and focusing on managing the enterprise mobile applications and the corresponding business data in your infrastructure are, arguably, more relevant capabilities to enable the mobile-first enterprise. Contextualizing and Mobilizing Business DataOne of the holy grails of enterprise mobile infrastructure is to enable mobile applications to leverage data hosted in corporate business systems. It may be conceptually trivial, but the process of mobilizing business data can be extremely challenging.In order to enable a mobile-first enterprise experience, organizations need to build the infrastructure to contextualize business data so that it can be effectively consumed on enterprise mobile applications. While technologically challenging, building the infrastructure to effectively mobilize data from corporate systems can drastically simplify the experience of incrementally building enterprise mobile applications. Mobilizing Existing Business ProcessesSome of the most successful organizations are the ones that have been able to redefine existing business processes using a mobile-first approach. In this model, traditional business capabilities – enabled via a desktop experience – will be simplified and redesigned for smartphones or tablets in order to provide an optimal productivity experience. Creating Mobile-First Business ProcessesIn addition, enterprises are starting to create new business processes to enable new business capabilities using a mobile-first paradigm. Mobile point-of-sale (POS) or mobile customer relationship management (CRM) systems are some of the best examples of mobile-first business processes being enabled in today’s enterprises. This type of mobile-centric business capabilities is a key element in the DNA of the mobile-first enterprise and helps organizations achieve greater differentiation and agility in the current mobile economy. Leverage Mobile-First Business AppsThe previous sections have highlighted the importance of building the infrastructure to implement new enterprise mobile apps as an essential element to enable the mobile-first enterprise. Equally important, is for organizations to invest in the infrastructure required to adopt domain-specific mobile business apps available in the marketplace. As the adoption of mobile technologies increases in the enterprise, we are starting to witness a new generation of mobile-first business apps that are redefining both horizontal and vertical business capabilities. Enabling the infrastructure to adopt those new mobile business apps in an efficient, secure approach tailored to your enterprise can improve the journey to the mobile-first enterprise.Images courtesy of Shutterstock. jesus rodriguez What it Takes to Build a Highly Secure FinTech … Why IoT Apps are Eating Device Interfaces Role of Mobile App Analytics In-App Engagement Tags:#BYOD#Consumerization of the Enterprise#smartphones last_img read more

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Power tariff hike for farms goes

first_imgRattled by the intensifying agitation of farmers, the BJP government in Rajasthan on Saturday rolled back the increase in power tariff for agricultural consumers and announced that it would increase subsidy on connections to fill the gap, which will cost the exchequer ₹500 crore.The decision, announced by Minister of State for Energy Pushpendra Singh at a press conference here, will benefit about 11.50 lakh farmers, who were being mobilised by the Opposition Congress and CPI(M)-backed All India Kisan Sabha in different parts of the State.After a huge Kisan Sammelan organised at the Krishi Upaj Mandi in Sikar on February 2, the Kisan Sabha had announced a march to Jaipur during the state Assembly’s upcoming Budget session.last_img

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Sena has no respect left for Rane, says Subhash Desai

first_imgPune: While the Congress is reportedly trying to convince strongman Narayan Rane to remain in the party fold, the Shiv Sena appears to have no love lost for its former leader.Shiv Sena leader and State Industries Minister Subhash Desai said on Friday that “the Sena did not value Rane at all”.Speaking in Kolhapur, Mr. Desai dismissed speculation about Mr. Rane returning to the saffron party, terming the rumours “utterly false”. “We have no respect left for him. It makes little difference to us which party accepts him,” he said.There has been buzz about Mr. Rane defecting to either the Bharatiya Janata Party (BJP) or the Sena, ever since his meetings with top BJP brass like Nitin Gadkari and Amit Shah in January and April, respectively.Despite Mr. Rane downplaying his meetings with BJP leaders, he has been in touch with them, and has also hinted at returning to the Sena. Last month, on the eve of his 65th birthday, Mr. Rane had said he owed his political existence and achievements to the late Shiv Sena president Bal Thackeray.However, while the BJP top brass has expressed interest in bringing Mr. Rane on board, the Sena has been dismissive of his inclusion. Mr. Rane acrimoniously exited the Sena in 2005, after his relations with current party president Uddhav Thackeray soured.Mr. Rane served as Chief Minister for a brief period in 1999 when the Sena-BJP coalition came to power. He represented Kudal in Sindhudurg district as an MLA for six terms, before being trounced by the Sena’s Vaibhav Naik in the 2014 Assembly elections by more than 10,200 votes. Despite his influence in the region, popular anger against his strong-arm tactics coupled with sanction to controversial ecological projects were his undoing. Fallouts with former aides Rajan Teli and Ravindra Phatak, and the Sena’s Deepak Kesarkar further undercut his hold over the region.The election defeat, the steady erosion of the Congress in the recently concluded civic polls, along with Mr. Rane’s frequent clashes with local Congress leaders, have spurred speculation about his defection.last_img read more

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Manny Pacquiao relishes underdog tag vs undefeated Keith Thurman

first_imgPrivate companies step in to help SEA Games hosting “Beautiful. That’s what I like,” Pacquiao said in a story on the Manila Bulletin.READ: Manny Pacquiao arrives in New York for Keith Thurman fight press tourFEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsThe underdog tag also serves as additional motivation for the 40-year-old Pacquiao (61-7-2, 39 KOs), who is 10 years older than Thurman (29-0, 22 KOs).“It’s going to make me even more determined to win,” he said. Catholic schools seek legislated pay hike, too DA eyes importing ‘galunggong’ anew ‘Rebel attack’ no cause for concern-PNP, AFP PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss LATEST STORIES Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue The last time Pacquiao was the underdog was against Floyd Mayweather Jr. in 2015 when he lost by unanimous decision.The other time in the last 12 years was when he obliterated Oscar De La Hoya, who was forced to quit on his stool at the end of the eighth round, in 2008. Two-day strike in Bicol fails to cripple transportcenter_img Cayetano: Senate, Drilon to be blamed for SEA Games mess MOST READ FILE – Philippine boxing icon Manny Pacquiao poses for photos during a press conference shortly after arriving at the international airport in Manila on January 24, 2019, days after defeating US boxer Adrien Broner in Las Vegas. (Photo by TED ALJIBE / AFP)MANILA, Philippines—Oddsmakers have undefeated American Keith Thurman as the favorite over Manny Pacquiao ahead of their welterweight world title fight on July 21 (Manila time) at MGM Grand Garden Arena in Las Vegas.Pacquiao, boxing’s only eight-division champion, though, wouldn’t want it any differently.ADVERTISEMENT Sports Related Videospowered by AdSparcRead Next Don’t miss out on the latest news and information. View comments Duterte wants probe of SEA Games mess Magic Johnson blasts Lakers GM Rob Pelinka after shock exitlast_img read more

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