Team discovers new MRSA treatment

first_imgA team of researches led by Professor Shahriar Mobashery and Mayland Chang developed an antibiotic to combat Methicillin-resistant Staphylococcus aureus, or MRSA, a strain of a certain species of bacteria that is resistant to a considerable number of conventional modern antibiotics.“MRSA is a multi-drug resistant version of a very common bacterium called staph aureus,” Mobashery said. “Staph aureus grows in our skin, grows in our noses, and has been with humanity for a very long time. However, this version, which is drug resistant, first appeared in 1962 in the U.K. and has become a global problem.”Mobashery said understanding the biochemical properties of MRSA that allow it to resist the effects of conventional antibiotics gave them valuable information and resources to develop an antibiotic to respond to the problem.“How does this organism have these biochemical properties that make it so difficult for treatment? That is a question my lab concerns itself with,” Mobashery said. “We want to understand the basis for the drug resistance this very difficult organism has developed over the many decades after its appearance.“When we understand some of the details of the biochemical event, can we subvert them in a way that leads to the demise of the organism? The answer to that question is yes, and we have come up with strategies that lend themselves to specifically addressing the methods that MRSA has devised for resistance,” he said. “We are actually able to take that and turn [them] around to … kill the organism.”Mobashery said finding and developing the drug to exploit the weaknesses he and his team found in MRSA was a massive computational undertaking, narrowing  over 1.2 million candidates to just 118 compounds.“1.2 compounds were so called ‘docked’ and ‘scored’ and … then, out of a collection of 2,500 compounds that had promise, we did some further analysis on which one of those were worthy of pursuit because not all of them were easy to synthesize. So we wanted to ideally buy some of these compounds,” he said.“We ended up choosing the 118 compounds … because they were commercially available and synthetically accessible.”Mobashery said the compounds were observed to effectively destroy MRSA in mice infected with the bacteria and that he saw a promising future for his work with the organism with the help of the University and collaboration with other researchers,” Mobashery said.“In principle, the University is very much interested in exploring whether companies will step up and move this class of molecules forward into clinical trials. That is something we won’t be able to do ourselves and we need partners and that’s a possibility. But research is ongoing on MRSA because of our broad interest in this organism and I’ve been at it for something like a dozen years and I trust that in a dozen years I’ll still be at it.”Tags: antibiotic, drug-resistant bacteria, Mayland Chang, MRSA, Shariar Mobasherylast_img read more

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IMCA Speedway Motors Weekly Racing National Point Standings Through Aug. 30

first_imgIMCA Modifieds – 1. Jordan Grabouski, Beatrice, Neb., 1,198; 2. Brandon Beckendorf, Danube, Minn., 1,190; 3. A.J. Ward, Ionia, Mich., 1,186; 4. Cory Sample, Winnemucca, Nev., 1,177; 5. Anthony Roth, Columbus, Neb., 1,162; 6. Bricen James, Albany, Ore., 1,156; 7. Chaz Baca, Mesa, Ariz., 1,150; 8. Drew Armstrong, Alexander, Ark., 1,148; 9. Jay Noteboom, Hinton, Iowa, and Kelly Shryock, Fertile, Iowa, both 1,147; 11. Troy Cordes, Dunkerton, Iowa, and Matt Szecsodi, Clio, Mich., both 1,138; 13. Tim Ward, Chandler, Ariz., 1,134; 14. Bryce Garnhart, Shannon, Ill., and Tyler Limoges, Redwood Falls, Minn., both 1,132; 16. Jeffrey Abbey, Comanche, Texas, 1,128; 17. Josh McGaha, Abilene, Texas, 1,125; 18. Joel Rust, Grundy Center, Iowa, 1,124; 19. Zane DeVilbiss, Farmington, N.M., 1,117; 20. William Gould, Calera, Okla., 1,107.IMCA Late Models – 1. Matt Ryan, Davenport, Iowa, 789; 2. Todd Cooney, Pleasant Hill, Iowa, 788; 3. Jeremiah Hurst, Dubuque, Iowa, 787; 4. Andy Nezworski, Buffalo, Iowa, 780; 5. Rob Toland, Colona, Ill., 763; 6. Ryan Dolan, Lisbon, Iowa, 749; 7. Chuck Hanna, Port Byron, Ill., 733; 8. Darrel DeFrance, Marshalltown, Iowa, 727; 9. Joe Zrostlik, Long Grove, Iowa, 685; 10. Gary Webb, Blue Grass, Iowa, 680; 11. Shawn Cooney, Bondurant, Iowa, and Curt Schroeder, Newton, Iowa, both 669; 13. Chad Holladay, Muscatine, Iowa, 663; 14. Joe Ross, Thomson, Ill., 646; 15. B.J. Jackson, Clinton, Iowa, 641; 16. Terry Neal, Ely, Iowa, 640; 17. Eric Sanders, Sherrard, Ill., 634; 18. Justin Kay, Wheatland, Iowa, 611; 19. Nick Marolf, Moscow, Iowa, 605; 20. Chad Coyne, Orion, Ill., 570.IMCA RaceSaver Sprint Cars – 1. Kevin Ramey, Fort Worth, Texas, 794; 2. Tyler Drueke, Eagle, Neb., 767; 3. Mike Houseman, Des Moines, Iowa, 765; 4. Zach Newlin, Millerstown, Pa., 757; 5. Austin Mundie, Carrollton, Texas, 746; 6. Matt Richards, Lincoln, Neb., 744; 7. Trevor Serbus, Olivia, Minn., 727; 8. Dusty Ballenger, Harrisburg, S.D., 720; 9. Ethan Barrow, Bloomington, Ind., 719; 10. Jeff Wimmenauer, Greenwood, Ind., 714; 11. Zach Blurton, Quinter, Kan., 712; 12. Colin Smith, Sheldon, Iowa, 709; 13. Chip Graham, Lewisville, Texas, and Robert Vetter, Wolfe City, Texas, both 698; 15. Brandon Allen, St. Peter, Minn., 694; 16. Kenneth Duke, Selinsgrove, Pa., 693; 17. Kyle Smith, South Egremont, Mass., 692; 18. Elliot Amdahl, Flandreau, S.D., 688; 19. Jason Martin, Lincoln, Neb., 685; 20. Kyle A. Ganoe, Thompsontown, Pa., 684.IMCA Sunoco Stock Cars – 1. Mike Nichols, Harlan, Iowa, 1,200; 2. Damon Murty, Chelsea, Iowa, 1,183; 3. John Oliver Jr., Danville, Iowa, 1,176; 4. Westin Abbey, Comanche, Texas, 1,153; 5. Dan Mackenthun, Hamburg, Minn., 1,128; 6. Mark Adams, Fort Worth, Texas, 1,127; 7. Jason Wilkinson, Neligh, Neb., 1,120; 8. Andy Roller, Waco, Texas, 1,118; 9. Jason Rogers, Selden, Kan., 1,117; 10. Matt Speckman, Sleepy Eye, Minn., 1,114; 11. Derek Green, Granada, Minn., 1,110; 12. Troy Burkhart, Hays, Kan., 1,109; 13. Brian Blessington, Breda, Iowa, 1,107; 14. Devin Smith, Lake City, Iowa, 1,106; 15. Damon Hammond, Burleson, Texas, 1,097; 16. Colin Heim, Hoxie, Kan., 1,093; 17. Donavon Smith, Lake City, Iowa, and Norman Chesmore, Rowley, Iowa, both 1,092; 19. Travis Van Straten, Hortonville, Wis., 1,090; 20. Luke Sathoff, Jackson, Minn., 1,085.IMCA Sunoco Hobby Stocks – 1. Shannon Anderson, New Virginia, Iowa, 1,200; 2. Cory Probst, Brewster, Minn., 1,181; 3. Luke Wassom, Broken Bow, Neb., 1,175; 4. Jeff Ware, Columbus, Neb., 1,169; 5. Leah Wroten, Independence, Iowa, 1,168; 6. Tim Gonska, Brainerd, Minn., 1,152; 7. Cameron Wilkinson, Neligh, Neb., 1,150; 8. Tathan Burkhart, Hays, Kan., 1,149; 9. Brady Bencken, Oakley, Kan., 1,146; 10. Cody Williams, Minneapolis, Kan., 1,132; 11. Adam Goff, Minot, N.D., 1,118; 12. Brandon Nielsen, Spencer, Iowa, 1,109; 13. Allyn Myers, Berwyn, Neb., 1,103; 14. Drew Barglof, Sioux Rapids, Iowa, 1,096; 15. Brock Beeter, Minot, N.D., 1,094; 16. Adam Ayers, Adair, Iowa, 1,092; 17. Roy Armstrong, Beatrice, Neb., 1,087; 18. Bryce Sommerfeld, Fort Dodge, Iowa, 1,086; 19. Justin Wacha, Vinton, Iowa, 1,078; 20. Garrett Hager, Hays, Kan., 1,069.Karl Chevrolet Northern SportMods – 1. Matthew Looft, Swea City, Iowa, 1,192; 2. Lucas Lamberies, Clintonville, Wis., 1,178; 3. Cody Thompson, Sioux City, Iowa, 1,175; 4. Austin Luellen, Minburn, Iowa, and Chase Alves, Chandler, Ariz., both 1,171; 6. Tyler Soppe, Sherrill, Iowa, 1,170; 7. Austin Svoboda, David City, Neb., 1,154; 8. Austen Becerra, Carthage, Ill., and Jason George, Laveen, Ariz., both 1,153; 10. Dakota Sproul, Hays, Kan., 1,149; 11. Colby Fett, Algona, Iowa, and Tony Olson, Cedar Rapids, Iowa, both 1,145; 13. Jake McBirnie, Boone, Iowa, and Tony Rialson, Cottonwood, Minn., both 1,137; 15. Johnathon D. Logue, Boone, Iowa, 1,131; 16. Gage Neal, Ely, Iowa, 1,123; 17. Austin Howes, Memphis, Mo., 1,116; 18. Ethan Braaksma, Newton, Iowa, 1,115; 19. Kelly Jacobson, Fargo, N.D., and Brandon Setser, Davenport, Iowa, both 1,111.Smiley’s Racing Products Southern SportMods – 1. Gabe Tucker, Carbon, Texas, 1,184; 2. Rodney White, Ector, Texas, 1,159; 3. Jake Upchurch, Grand Prairie, Texas, 1,153; 4. Tyler Bragg, Springtown, Texas, 1,113; 5. Trevor Raney, Sherman, Texas, 1,096; 6. Taylor Florio, Copperas Cove, Texas, 1,080; 7. Dustin Robinson, Post, Texas, 1,039; 8. Kyle Wilkins, Italy, Texas, 1,013; 9. Ryan Thomas, Lubbock, Texas, 952; 10. James Skinner, Burleson, Texas, 938; 11. Cory Williams, Slaton, Texas, 927; 12. James Hanusch, Belton, Texas, 867; 13. Chris Cogburn, Robinson, Texas, 853; 14. Justin Nabors, Kemp, Texas, 834; 15. J.P. Vasquez Jr., Lubbock, Texas, and Brayden Wyatt, Wichita Falls, Texas, both 833; 17. Chase Vineyard, Davis, Okla., 808; 18. James McCreery, Midlothian, Texas, 803; 19. Edward Grmela Jr., Hewitt, Texas, 792; 20. Frank Groves, Shallowater, Texas, 775.Mach-1 Sport Compacts – 1. Ramsey Meyer, Pierce, Neb., 1,195; 2. Dustin Virkus, Clarkfield, Minn., 1,172; 3. Oliver Monson, Clear Lake, Iowa, and Barry Taft, Argyle, Iowa, both 1,154; 5. Alex Dostal, Glencoe, Minn., 1,152; 6. Bubba Brown Jr., Jackson, Minn., 1,149; 7. Curtis Miller, Lewis, Iowa, 1,138; 8. Jay DeVries, Spencer, Iowa, 1,137; 9. Andrew Harris, South Sioux City, Neb., 1,110; 10. Kaytee DeVries, Spencer, Iowa, 1,083; 11. John Martinez, Beatrice, Neb., 1,074; 12. Terry Tritt, York, Neb., 1,073; 13. Shawn Hein, Beatrice, Neb., 1,071; 14. Howard Watson, Weatherford, Texas, 1,067; 15. Scott Newbury, Rhome, Texas, 1,053; 16. Julia Childs, Weatherford, Texas, 1,050; 17. Brock Klaith, Marshall, Minn., 1,041; 18. Joshua Young, Beatrice, Neb., 1,019; 19. Austin Friedrich, Saint James, Minn., 1,009; 20. Ashlee Kelly, Fairmont, Minn., 967.last_img read more

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