Gullit insisted that Liverpool need to improve for the final

first_imgRuud Gullit believes that Liverpool simply can’t allow playing like they did in the semifinals against AS Roma – otherwise, they can receive a harsh lesson by Real Madrid as they are far more experienced.Jürgen Klopp’s men will have to play more focused and be better defensively if they want to win the famous trophy – because Real Madrid will be able to punish every single one of their mistakes.The Dutch legend spoke about Liverpool’s chances as he said, according to Team Talk:“If Liverpool are going to play like they did in Rome, they are not going to win the Champions League.”divock origi, liverpoolReport: Origi cause Klopp injury concerns George Patchias – September 14, 2019 Divock Origi injury in today’s game against Newcastle is a cause for concern for Jurgen Klopp.Perhaps with one eye on Tuesday’s trip to Italy…“It is fantastic to have Liverpool in the final, but everyone must realise that they only scraped through at the end.”“I have read the verdict of some former Liverpool stars and they are euphoric. They are not impressed by Real Madrid. They think Liverpool have a serious chance of winning.”“But the players and coaching staff of Real will have watched Liverpool’s second game against Roma. And I think they will have drawn the strong conclusion that they have more of a chance to win the final than Liverpool.”last_img read more

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Frenkie de Jong wouldve loved Lionel Messis number 10

first_imgDutch midfielder Frenkie de Jong joked with the idea of possibly getting Lionel Messi’s number ’10’ jersey at Barcelona when he arrived next summer.The biggest news in Spanish football for the last couple of days has been Frenkie de Jongs transfer to FC Barcelona, a deal that was completed last Wednesday and will have the Dutchman playing alongside the likes of Lionel Messi.The Argentine forward was reportedly crazy for getting the Ajax midfielder signed, which is something that motivated De Jong for making his final decision.The player is set to start his new journey at FC Barcelona next summer, he will finish the current season at Ajax in all competitions and then report to the manager on July 1st.During an interview with De Telegraaf, Frenkie opened up about the number he could use at the Catalan club and joked with the idea of possibly taking it away from Lionel Messi.But all kidding aside, the player revealed that he still hasn’t decided which number he will sport for the rest of his career at Barcelona and he is possibly waiting for any changes that happen by the end of the season.The Spanish giants are expected to get rid of at least one of the big players in the squad, the money right now is on Brazilian Philipe Coutinho who hasn’t lived up to the hype since he arrived from Liverpool.De Jong: “I want number 10, but I think someone already has it.”#EnjoyDeJong pic.twitter.com/3LRqsgsEz9— Penya FCB de Beirut (@PenyaFCBBeirut) January 24, 2019Another option for FC Barcelona is to sell Croatian midfielder Ivan Rakitic, who has come a long way since he arrived in the club from Sevilla and possibly has already fulfilled a cycle as he approaches the final stages of his career.As we all know, Ivan Rakitic sports the number ‘4’ jersey, a traditional number at FC Barcelona that have worn historic players like Ronald Koeman or Pep Guardiola.It would be only fitting for Frenkie to follow in those footsteps once Ivan Rakitic decides to call it quits, this scenario is more plausible than the jokes De Jong made in regards to taking Lionel Messi’s number ’10’.Because as we all know by now, the Argentine will wear this jersey until the day he decides to retire. Hopefully for all football fans, that day won’t come any time soon.But that number ‘4’ jersey does seem like the most likely path for the Dutch midfielder, he fits the position and has what it takes to become the next great FC Barcelona player.FC Barcelona, Valencia CFMatch Preview: Barcelona vs Valencia Boro Tanchev – September 14, 2019 Is derby time in La Liga, as Barcelona welcomes Valencia to the Camp Nou Stadium tonight at 21:00 (CET).But even Ivan Rakitic’s exit from the club is not a sure thing, mainly because manager Ernesto Valverde has repeatedly said that the Croatian midfielder is a key player in his squad.Esto es Frenkie de Jong… 😍#FrenkieFuturo pic.twitter.com/L8qGei6Bp5— AFC Ajax (@AFCAjax) January 23, 2019Frenkie de Joong has been talking to several news outlets during these past two days, but the very first interview he offered was to Dutch outlet De Telegraaf because they were the ones with the inside information and the very first outlet that spoke about the specifics of De Jong’s transfer from Ajax to Barcelona.The player granted an interview where he discussed several topics, but the subject of the number he will wear was specifically addressed.“No, there is still no number on that jersey. That will come later. Yes, I would obviously love wearing the number ’10’ jersey but I think someone is already playing with it at Camp Nou,” he laughed.“Lionel Messi, I think. That number won’t be mine. He is the best and I believe it’s an honor to be his teammate.”“Right now, I really can’t picture myself next to him on a football pitch. However, I won’t be some kind of tourist who only enjoys Messi play.”“I am doing everything I can in order to become a fundamental player for FC Barcelona,” he concluded.El pequeño Frenkie de Jong, la nueva perla del Barcelona. pic.twitter.com/YHv7aE3rwY— El Mister (@el_Mister8) January 24, 2019Which number would you prefer Frenkie de Jong could wear at FC Barcelona? Please share your opinion in the comment section down below.last_img read more

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Royal Robinson knocks PDM Budget allocations says priorities wrong

first_imgFacebook Twitter Google+LinkedInPinterestWhatsAppTurks and Caicos, April 20, 2017 – Grand Turk – Opposition Member Royal Robinson knocked the PDM government’s first budget, calling it lip service to the Turks and Caicos people.In his contribution to the Budget Debate, Robinson questioned the amounts of $450,000 set aside for the Health sector, an amount he says should have been atleast $600,000. He added that Health issues such as diabetes needed serious attention, and that more was needed in the combat against mosquito borne diseases. Robinson told the house that the TCI people got a six for a nine in voting them into government. He added that the Agriculture sector, also received lowered amounts than previous budget allocations.The PNP member went on to dismiss the Government’s 12 Point Crime plan, calling on the PDM to provide solutions to the current crime situation.  Meanwhile, Robinson called out the Premier on her description of him as the “Destructive New, new PNP”, saying he was only doing the job his party had put him there to do, and that he was far from destructive.#Story by: Kimberly Ramkhalawan            #MagneticMedianews#prioritieswrongsaysroyalrobinson#RobinsonknocksPDMbudget Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:#magneticmedianews, #prioritieswrongsaysroyalrobinson, #RobinsonknocksPDMbudgetlast_img read more

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Local Entrepreneurs Display Talents Tomorrow For Lemonade Day

first_imgJohna Beech, President of the Kenai Chamber of Commerce: “When you are cruising out and about on Saturday and you see a kid with a lemonade stand, stop by and buy one or two cups.” Facebook0TwitterEmailPrintFriendly分享For the past seven years, local Chambers of Commerce have been helping young residents learn the basics of entrepreneurship through Lemonade Day. This year’s event is scheduled June 9. Local children have participated in the Chambers’ building and finance workshops, learning how to create a product and a store and how to use the proceeds. Andrew Heuiser, Events & Programs Coordinator for the Soldotna Chamber of Commerce: “Lemonade Day is an education program for youth in the community and they learn how to start up their own business , run it, and make profits, and do what they want to with those.” Lemonade Day is a free, experimental learning program that teaches youth how to start, own and operate their own business – a lemonade stand.  Each child that registers receives a backpack with an Entrepreneur Workbook that teaches them the 14 lessons of Lemonade Day like creating budgets, setting profit-making goals, serving customers, repaying investors, and giving back to the community. Along the way, they acquire skills in goal-setting, problem solving, and gain self-esteem critical for future success. They keep all the money they make and are encouraged to spend some, save some and share some. Lemonade stands will be popping up on Saturday in front of many established local businesses in the Soldotna-Kenai area.last_img read more

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Discord Slack for gamers tops 250 million registered users

first_img Share your voice Culture Gaming 0 Post a commentcenter_img Many gamers these days like to play online with friends. Discord helps them do that. Getty Images You may never have heard of Discord, but you might soon. The chat app built initially for gamers has been steadily expanding outside that world as it’s increasingly used by YouTube personalities, podcasters, hackers and more. Overall, the company says it counts more than 250 million registered users, or basically the same number of people who’ve signed up to play the cultural phenom Fortnight. More than 56 million people log in each month on the app, which marks its fourth anniversary Monday. “As Discord has grown, it’s gone mainstream,” the company said in a statement. direct-message-screenDiscord is praised for its sleek design, similar to business chat software Slack. Discord While it’s true the 165-person company has become popular outside of gaming, its most popular “servers” (or, chat rooms) are typically gaming related. The top server is for Fortnite, followed by a similar battle game Spellbreak, then Fortnite competitor PUBG. Microsoft’s world building game Minecraft, Supercell’s strategy game Clash Royale and Ubisoft’s Rainbow 6 military survival game are also popular. Its good-natured gaming roots and slick design have made it popular among gamers looking to easily chat with friends or organize a gaming session from across town or on another side of the world. It’s often called “Slack for gamers,” a reference to the similarly designed business software that’s expected to hold an initial public offering this year. But Discord has a darker side. White supremacists and hackers have gravitated to the platform, in part because of its ease of use and insufficient bureaucracy to track and punish them. That’s different from companies like Facebook and Twitter, which have employee bases many times larger than Discord’s and have taken a harder line, even using computer programs to identify and then excise bad actors from their communities.  Still, San Francisco-based Discord is pushing forward. It’s launched a game sales service to compete with the likes of Fortnite maker Epic and Valve’s popular “Steam” store. The company declined to say how many games it’s sold through that effort.  Tagslast_img read more

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Paytm to take longer than expected to return profits amid surging losses

first_imgMobile payments company Paytm is likely to take longer than previously thought to turn around as competition heats up, a report says. The losses of the company’s parent One97 Communications are likely to double in the short-term, topping Rs 2,100 crore in fiscal 2020 ending on March 31, 2020, a media report said quoting a consultant.The losses in the current fiscal, FY19, are estimated at Rs 870 crore, according to the report prepared by the Corporate Professionals Capital. The company may turn around in FY21 notching up a profit of about Rs 200 crore, the report says.Mint suggests that 97Communications may achieve a profit of over Rs 8,500 crore by the financial year 2025-26. Sources attribute the increasing losses to the company’s aggressive expansion strategy as large corporate houses are entering the mobile payment field.Amazon and Walmart have announced their intent to enter the UPI payment scenario, apart from a clutch of banks and other financial institutions. Google Pay is also threatening to heat up the competition.A source told Mint that the company may tone down its expansion-oriented strategy to rein in the losses. “The company is now planning to significantly scale down its cash-burning online businesses or selling stakes in them and augment its offline business ventures,” the report cites the source as saying. Paytm hopes that its new hire Raghu Chakravarthi from online grocery retailer BigBasket will help its online-to-offline business strategy.The company’s net cash flow is expected to remain negative at Rs 1,400 crore in the next financial year, rising from the current year’s Rs 580 crore. Warren Buffet’s Berkshire Hathaway Inc bought an undisclosed stake in One97 in August for $356 million helping Paytm remain liquid.One97 has launched 25 subsidiaries and five associate firms, including Paytm Payments Bank Ltd, LogiNext Solutions, SoCoMo Technologies and QorQL in a space of 12 months. Eight of the company’s subsidiaries suffered significant losses during the financial year that ended on March 31, 2018.The digital payments service has remained the company’s mainstay while its online retail business has been bleeding money. Paytm still leads the pack in digital payments, according to estimates.Paytm Mall, the company’s online retail business, suffered Rs 1,787 crore loss against revenue of Rs 775 crore during FY18, according to the company’s regulatory filings.One97 Communications’ took in total losses of about Rs 1,600 crore during the FY18, almost against Rs 900 crore in the previous year.Financial experts say the mounting losses and negative cash inflows have made it crucial for One97 Communications to enhance its working capital limit.A recent report said Paytm had pledged all its current assets and mutual fund investments to be able to borrow Rs 1,400 crore from private lender ICICI Bank.last_img read more

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Netflix Stock Slips After Streamer Announces 19 Billion JunkBond Offering

first_imgNetflix hasn’t been secretive about plans to assume more debt, regularly informing investors of its intentions to issue more junk bonds (which carry a higher yield and higher risk than investment-grade bonds).“[W]e believe the debt is lower cost of capital compared to equity,” as the company said in its April 16 shareholder letter.The $1.9 billion proposed debt offering is the biggest in Netflix’s history, and the fifth time in a little more than three years that Netflix is raising $1 billion or more through bonds. As of March 31, Netflix had $6.54 billion in long-term debt and $17.9 billion in streaming content payment obligations (of which $3.44 billion are long-term content payment obligations). Popular on Variety Netflix’s eye-popping rise on the stock market has hit a speed bump: Shares of the streaming giant fell as much as 5% Tuesday, after the company announced its biggest junk-bond offering to date.The sell-off came after Netflix on Monday evening priced $1.9 billion in debt financing, cash it intends to use to feed its growing appetite for original programming. The company has projected a content budget of $7.5 billion to $8 billion for 2018.Shares were down 4.2% as of 1:40 p.m., to $305.32 per share; Netflix stock closed down 2.8% Monday after it announced initial $1.5 billion debt-funding plans. [UPDATE: Shares closed Tuesday down 3.7%, to $307.02, putting Netflix’s market cap at $133.5 billion.] Still, the stock is trading up more than 50% since the beginning of the year.The dip signals investor potential concern about Netflix’s heavy cash-burn strategy. The company is forecasting free cash-flow to be negative in 2018 — to the tune of as much as -$4 billion — and says that will continue for the next few years. The stock decline could also reflect profit-taking after shares have hit record highs this month, after Netflix posted strong first-quarter 2018 subscriber net adds in spite of a multi-territory price hike.center_img ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15last_img read more

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Lodestars of Indian classical music

first_imgShriram Shankarlal Music Festival, the oldest music festival in the country has very successfully carried forward the tradition of incorporating a noteworthy synergy of the skills – of the country’s eminent maestros, with the vibrancy of exceptional young talent, without alienating the intrinsic heritage. Founded in 1947, the Shriram Bhartiya Kala Kendra propagates Indian classical performing arts, mythological, contemporary and folk productions of epics. Also Read – ‘Playing Jojo was emotionally exhausting’The festival is back to enthrall the Delhiites. Commencing on February 19, the festival presents Shehnai by Sanjeev Shankar and Ashwani Shankar  and vocal by Pandit Jasraj on the opening day. Sanjeev Shankar and Ashwani Shankar were born in a family of musicians of Banaras gharana in which shehnai and flute have been played for the last 450 years and over, after formal training in pursuit of proficiency of the highest order in raga, taaland laya.Pandit Jasraj, the Mewati maestro, endowed with a rich, soulful and sonorous voice which traverses effortlessly over all three and a half octaves. He has won several prestigious awards and honours, including the Padma Vibhushan, Sangeet Kala Ratna, Master Dinanath Mangeshkar Award, Maharashtra Gaurav Puraskar, Marwar Sangeet Ratna Award and the Sangeet Natak Akademi Fellowship. Also Read – Leslie doing new comedy special with NetflixThe second day of the festival will witness vocal by Raghunandan Panshikar and santoor rendition by Shiv Kumar Sharma. Raghunandan Panshikar commands in semi-classical genres (thumri, ghazal, bhajan, abhang, etc.) accounts for his versatility and singularity among Hindustani vocalists. Awards. Shiv Kumar Sharma has started a new genre of instrumental music. Through his performance career of over half a century, he has created millions of new listeners and ardent fans of Indian classical music. His performances are a brilliant combination of rich knowledge, perfect skill and abundant, spontaneous creativity an adherent of the Banaras gharana, Shiv Kumar Sharma has a long list of national and international awards.Third day of the festival will bring to you vocal by Manjiri Asanare  and flute by Hari Prasad Chaurasia. Born in a family of musicians, Manjiri’s interest in music developed under the guidance of Pt. C T Mhaiskar of Sangli. She has now been performing at prestigious music festivals, and has gained recognition as a fine upcoming musician of the Jaipur gharana.Natural talent, deep dedication, fine training and years of rigorous riyaz have made Chaurasia one of the top flutists in India today. Hariprasad Chaurasia has been honoured with several prestigious awards including the Padma Vibhushan.Day four will see vocal by Ritesh and Rajnish Mishra  and sarod rendition by Tejendra Majumdar, dhrupad rendition by Uday Bhawalkar followed by vocal by Ajoy Chakrabarty . Ritesh and Rajnish Mishra have been learning music since their birth with sounds of tanpura, sarangi, tabla and voices of forefathers vibrating in their home and surroundings. Tejendra Majumdar was awarded the President’s gold medal and the Pandit D V Paluskar award. Uday has also collaborated with artists from other disciplines and cultures, including the contemporary dancer Astad Deboo, Ensemble Modern in Germany and musicians from Spain, Georgia and USA. Pandit Ajoy Chakrabarty became a disciple of Ustad Munawar Ali Khan, the son of the great Patiala Maestro Ustad Bade Gulam Ali Khan. He is the first recipient of the Kumar Gandharva award.When: February 19 – 22  Where: Kamani Auditorium, 1, Copernicus Marglast_img read more

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Fed QE3 Asset Purchase Program to End In October

first_img in Daily Dose, Featured, Government, News October 29, 2014 430 Views Fed: QE3 Asset Purchase Program to End In October Economy Federal Open Market Committee Meeting Federal Reserve FOMC Labor Market Mortgage-Backed Securities QE3 Asset Purchase Program 2014-10-29 Seth Welborncenter_img The Federal Open Market Committee (FOMC) of the Board of Governors of the Federal Reserve System today announced that its asset purchase program, known as QE3 (quantitative easing), will end this month, citing sufficient economic growth.Following months of speculation of the end of the program, Fed made the announcement in its FOMC statement, following the FOMC’s seventh of eight meetings this year which took place today. Unlike the Fed’s first two QE programs, which were launched in 2008 and 2010, QE3 allowed for the unlimited purchase of mortgage-backed securities; the Fed planned to continue the stimulus program until the economy was deemed healthy enough.The Fed suggested in today’s FOMC statement that U.S. economic activity is expanding at a “moderate pace” since the Committee’s last meeting on September 17.The Committee cited several factors in its assessment of the state of the economy. Since the start of September, the nation has experienced solid job gains and posted the lowest unemployment rate in six years, and labor market indicators show a gradual diminishing in the underutilization of labor resources. The housing sector has been slow to recover from the crisis of 2008, but household spending rose moderately and business fixed investment is advancing.With the substantial improvement in the outlook for the labor market, as judged by the Committee, since the inception of the QE3 asset purchase program two years ago and the broader economy’s underlying strength to support ongoing progress toward maximum employment in a price stability context, the Committee decided to conclude the QE3 program this month.”The Committee is maintaining its existing policy of reinvesting principal payments from its holdings of agency debt and agency mortgage-backed securities in agency mortgage-backed securities and of rolling over maturing Treasury securities at auction,” the Committee’s statement said. “This policy, by keeping the Committee’s holdings of longer-term securities at sizable levels, should help maintain accommodative financial conditions.”In order to support continued progress toward maximum employment and price stability, the Committee decided in today’s meeting that the current zero to one-fourth percent target range for the federal funds rate is still appropriate. The Committee will assess both realized and expected progress toward the objectives of maximum employment and 2 percent inflation in order to determine how long to maintain the current target range for the federal funds rate.The Committee said it will use a wide range of information to determine how long the current target range will be appropriate, including labor market conditions, inflation pressures and expectations, and financial development readings. The current target range could be in place for a while, the Committee said.”The Committee anticipates, based on its current assessment, that it likely will be appropriate to maintain the zero to one-fourth percent target range for the federal funds rate for a considerable time following the end of its asset purchase program (QE3) this month, especially if projected inflation continues to run below the Committee’s 2 percent longer-run goal, and provided that longer-term inflation expectations remain well anchored,” the Committee’s statement said.Increases in the target range for the federal funds rate could come more quickly if the Committee’s employment and inflation objectives are met sooner than expected, the Committee said. If information indicates that the Committee’s employment and inflation objectives are taking longer than anticipated to be met, then an increase in the federal funds rate target range could come much later than expected.The Committee’s next meeting is scheduled for December 16-17. Sharelast_img read more

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Portfolio Underwriter is Now Available through Calyx Software

first_img automated underwriting system Calyx Software Fair lending Portfolio Underwrite 2017-06-16 Staff Writer Calyx Software, a provider of comprehensive mortgage software solutions for banks, credit unions, mortgage bankers and brokers, announced Portfolio Underwrite, an automated underwriting system (AUS) from LoanScorecard, is now available to Point and PointCentral clients.“Manually underwriting portfolio loans not only exposes lenders to Fair Lending issues, but is also time consuming and costly,” said Ben Wu, Executive Director at LoanScorecard. “By incorporating automated technology like Portfolio Underwriter, portfolio lenders using Point and PointCentral can improve efficiency by streamlining decisioning for their unique programs and focus on more complex transactions.”Portfolio Underwriter allows portfolio lenders to customize credit decisioning and safely originate non-agency loans that they intend to put on their balance sheets. It captures a portfolio lender’s program guidelines within its engine and delivers a rules-based underwriting decision in seconds. Results of the decision are documented in a findings report. This report includes program-specific, conditional underwriting criteria utilized in the data analysis.Portfolio Underwriter seamlessly integrates with Calyx Point and PointCentral loan origination systems. The connection facilitates bidirectional data flow and provides a single system of record for all loan documentation. Centralization of processes and documents streamlines preparation for audits, board reviews and regulatory submissions.“The predominant focus of Fair Lending violations is how and why loans were approved; therefore, it is critical to have an AUS in place to demonstrate the standard practice of quality underwriting,” said Bob Dougherty, VP of Business Development at Calyx Software. “While lenders are certainly familiar with agency AUS, they are also aware of gaps in automated decisioning for their portfolio products. Portfolio Underwriter helps lenders who originate portfolio loans automatically determine the appropriate response for their institution—ensuring compliance with Fair Lending at the point of sale and in the underwriting process.” in Featured, Headlines, News, Technology Portfolio Underwriter is Now Available through Calyx Softwarecenter_img June 16, 2017 596 Views Sharelast_img read more

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Go back to the enewsletter Fresh from being awa

first_imgGo back to the e-newsletter >Fresh from being awarded for Top Australia/New Zealand Production at Virtuoso Travel Week , David Goldman, Joint Managing Director of the Goldman Travel Corporation, chats with LATTE about the value of travel advisors, trends and Viennese coffee. How did you become one of Virtuoso’s top booking agents in Australia and New Zealand?Over the past couple of years, we have been aligning with like-minded agencies, acquiring Australia’s top agencies, which we couldn’t have done without people such as Cher [Roscoe] from Travelcall and Fay Cohen from Travel Phase, now under the Goldman Group umbrella. We have also brought SmartFlyer to Australia, a New York-based company that is very social media-driven, and are looking to the next generation of travellers. Throughout all that, we’ve remained a family company since 1983, with my father Tom still serving as Executive Chairman. Our aim was to become the best in the business, and we have achieved that. How have you seen the travel industry change?I’ve been in the travel industry for 20 years and about 8 years ago, people were talking about the death of travel agents. Now we’re the heroes. We sift through and curate the plethora of information that exists to offer our clients experiences that you can’t get online for the best price. In a world of online DIY, why do clients seek you out? What specialisations mark you out?We can also offer that little bit of ‘sugar on top’; as we say, you can’t VIP yourself but we can VIP our customers. Goldman Group has the contacts needed, thanks in large part to Virtuoso; we’ve been a member of that network for 12 years now. Being able to tap into that wealth of expertise is the best thing we have ever done and the ability to meet with its network of top operators is invaluable to your business. It’s a cliché, but we are dream makers. We turn clients’ hard-earned cash into the best travel experience, and we’re leaders in that arena. In reality, we are not competing with online at all. What travel trends are you noticing for 2015/16?Europe is always in demand. We’re seeing Italy particularly popular for multi-generational trips. Sri Lanka is also high on people’s lists and we’re also looking to see which destinations will be popular next with the help of social-media savvy ‘trendsetter’ clients. In terms of types of travel, experiential travel is the most in-demand, and volunteering is increasingly requested. We arrange for clients to do things like teach English in the hills of Thailand, but come home each night to a luxury hotel. Cruises are also big right now. What hotel openings or (re-openings) are you most looking forward to for the coming year?The Lanesborough in London, part of the Oetker Collection, has unveiled its latest refurbishment, and so has The Goring; these are the best hotels in the world as far as I’m concerned. I’m also looking forward to staying at the refurbished Plaza Athénée Paris after ILTM this year. The new Baccarat Hotel in New York is very exciting, as is the Park Hyatt New York, which opened in October 2014; a gorgeous and cool property. I’m also keen to see the new Trump property in Bali. What are the greatest lengths you’ve gone to for a client?Everything. We’ve organised private transfers (helicopter, private jet, boats), private tours of the Sistine Chapel and Yankee Stadium, we’ve chartered cruises in the Mediterranean. We’ve recently organised a proposal on Hayman Island, with a helicopter trip out to Whitehaven Beach. If you could send a client anywhere, where would it be?Italy. As I’ve said, it’s always popular, it never disappoints and it’s great for the whole family. For those who love the sun, you can’t go wrong with the Maldives, Mauritius, Tahiti. London and France are classics. Central Europe is also great – Croatia, Hungary – as is Spain and Sri Lanka. What are your top tips for organising a client’s honeymoon?Be organised. We can help in any number of ways, be that making sure that the climate is spot-on when the client is planning to go (climate is surprisingly important), making restaurant reservations and organising a pre-arrival contact. The destination and style has to suit the couple; are they after fly and flop, looking to explore or wanting to hit the shops? Figuring out what a couple really wants, however, is often a matter of gut feeling, based on what they’ve told us. It must always be a beautiful experience and value for money. What’s the quirkiest request you’ve had to accommodate?No request is too quirky. That’s why we’re there. Our job is not finished until the client comes home, so we offer hands-on management every step of the way to make sure everything goes smoothly. For us, we love what we do. Best coffee you’ve ever had?Hotel Imperial in Vienna. It’s a beautiful Luxury Collection property and the Austrian coffee and cake culture, the historical, indigenous experience of people watching made it a whole experience, rather than just a cup of coffee.www.goldmantravel.com.auwww.hotelsmakeushappy.comGo back to the e-newsletter >last_img read more

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Petoskey Mayor attends State of the State address as Rep Chatfields special

first_img21Jan Petoskey Mayor attends State of the State address as Rep. Chatfield’s special guest State Rep. Lee Chatfield was pleased to welcome his wife, Stephanie and Petoskey Mayor Bill Fraser to the Capitol on Tuesday as his special guests for Gov. Rick Snyder’s annual State of the State address.“I am honored to represent the residents of Petoskey at this historic event,” said Mayor Bill Fraser. “I look forward to working alongside Rep. Chatfield to accomplish great things for the people of northern Michigan.”Rep. Chatfield, R-Levering, issued the following statement regarding the governor’s address: “I am eager to work with Gov. Snyder to continue moving Michigan in a better direction. I agree with the governor that innovation is the key to reforming the way our state government works, and I fully support his endeavor to make Michigan government more efficient and transparent.”“In order to ensure that Michigan remains vibrant for future generations, I agree with the governor that we must emphasize vocational training in our education. Let’s continue to innovate our state and make Michigan an even better place to live, work and raise a family,” concluded Rep. Chatfield. Categories: Chatfield News,Chatfield Photos,Newslast_img read more

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Dear Reader Coal plays an integral role in keep

first_imgDear Reader, Coal plays an integral role in keeping the lights on and buildings standing. Despite the green energy movement, more than 40% the world’s electricity still comes from coal-fired plants, and 70% of the world’s steel production requires metallurgical coal. This graphic from the World Coal Organization reviews the types of coal and what they’re used for. Japan continues to be the #2 global producer of steel. Annual production for 2013 accounted for approximately 7% of global supply, which means it’s a significant importer of metallurgical coal. Japan gets most of its thermal and met coal from Australia: 72% and 52%, respectively. Indonesia is its second-largest supplier at 13% and 27%. India ranks #3 in the world in differential between exports and imports for coal. With a population of over 1 billion, a population growth rate of over 1%, and a GDP growth rate of over 3%, its demand for power is relentless. Of measured, indicated, and inferred coal in India, 232 billion tons of its total 264 billion tons fall into the category of non-coking coal. While lignite may be used for power generation in areas with relaxed environmental policies, the ability to export coal will be limited, likely requiring India to remain a net importer. Like many of the Asia-Pacific countries, South Korea is and will continue to be heavily dependent upon energy imports. Of its total $150 billion in imports of oil, liquefied natural gas (LNG), and coal, oil represents about $110 billion and coal less than $20 billion. But thanks to the country’s growth rate, on a percentage basis coal demand has increased by 550% over the last 10 years. The latest South Korean energy policy is aimed at raising coal briquette prices, a move to slow demand that suggests a shift toward LNG as the country’s main long-term power source. The price difference between the two comes largely from proximity to final destination. The coal spot market in Asia has taken off tremendously over the past year, with 67.7 million tons traded over 2013. Major Players and Their Reserves Total global reserves are over 860 billion tons, with anthracite and bituminous coals accounting for 404 billion tons (47%). At current production rates, the world has 109 years of reserves left. Indonesia is the world’s #1 producer and exporter of thermal coal. Currently, it exports nearly 80% of its production. However, the government has put a cap on coal production for 2014, as it’s trying to put future domestic interests ahead of international trade. The current reserves-to-production ratio stands at approximately 79 years. A new Indonesian mining law introduced in 2014 banned the export of raw ore, which means all coal refining must be done domestically. The government has also stated plans to raise royalties from the 3-7% range (depending on type) to 13.5% for all coal types. Port congestion has become an issue for the exporters; wait times have increased by nearly 30% to 6.7 days, in contrast to the one- to two-day average in other Asian ports. It’s one symptom that shows how reinvestment in the country’s port infrastructure is crucial to further development of its export market. Just across the Timor Sea from Indonesia is Australia. The Land Down Under currently occupies the #2 spot of coal exporters, but it dominates the global forecast for coal production. Nearly 50% of coal reserves in Australia fall into the “hard coal” category, an advantage in coming years as environmental regulations get tougher. The Australian government has big plans over the next several years to expand infrastructure that will add 80 million tons of port capacity, as well as to ramp up 65 million tons of production capacity. In total numbers, the export forecast is 327 million tons (23%) of the world’s steam, or thermal, coal. Metallurgical coal production is expected to be 259 million tons, which will account for 54% of global met production. Russia holds the second-largest coal reserves in the world, with a reserves-to-production ratio of 443 years. Russian energy policy actually is going in the opposite direction of most of the West, by decreasing natural gas power generation and raising coal-fired generation. Additionally, the coal industry in Russia has been restructured, leading to the privatization of coal assets. All coal mining is now carried out by joint-stock companies with private ownership. There’s not a lot new to say about Colombia, the fourth-largest coal exporter in the world and the largest in South America by a considerable margin. Colombian reserves are 94% anthracite and bituminous coal and are the primary suppliers of coking coal for Brazil. In contrast, South Africa shows potential to be a hot new region for coal with the discovery of the Waterberg area play. In 2012, the state-owned rail company announced plans to build Swazilink, a railway from the Waterberg coalfield in northeastern South Africa and the port at Richards Bay that would increase export capacity along with several feeder lines. The United States, too, continues to be a major producer of coal; however, production has dropped off every year since 2007. Coal production for 2013 was down 27% to 744.8 million tons as tougher environmental regulations weakened domestic demand. Coal-fired power plants are subject to the Mercury and Air Toxics Standards (MATS), scheduled to take effect on April 16, 2015. Tough domestic regulations don’t necessarily spell doom for the American coal industry as long as other countries in the world still operate coal-fired power plants. Nearly half of its reserves are the desirable anthracite and bituminous coals. Future Supply The growth forecast for total steam- and met-coal exports is 39% by 2040. Here’s a summary of expected exports by kind and country. New developments can alter the standings, however—among those just mentioned here, there’s the proposed air-quality legislation in China and Indonesia’s protectionist trend. Exports (millions of tons) 258.82 82.01 36.98 27.33 47.91 24.74 Coal Cycle Once the downtrend in coal prices approaches the minimum level a company needs to make a profit, an unpleasant conundrum arises: Should it stop producing until prices pick up, or should it increase its production to try to maintain its revenue levels? Sometimes a company has to keep up production or go bankrupt—but if consumption doesn’t keep up with production, the excess supply can put even more downward pressure on prices. The coal sector is currently in this exact situation. Major producers such as BHP, Glencore Xstrata, and the like have suspended operations due to poor economic conditions. So let’s examine the demand in the coal market. Major Coal Consumers The international coal trade is forecast to grow by 65% from 24 quadrillion BTU in 2010 to 39.6 quadrillion BTU in 2040. To put those figures in perspective, one rail car holds about 120 tons of coal, which is approximately 2.3 billion BTUs. If you were to load the 2040 global trade for coal into rail cars, strung together the cars would circle the earth over 6 times. Supply-Side Economics Like other mainstream commodities, coal has a spot price; but many trades take place off-exchange. For trades that do take place on an exchange, the two most common benchmarks are Central Appalachian coal, produced in the eastern United States, and Australian thermal coal, produced mostly in eastern Australia. China is the 800-pound gorilla in the coal market, both in reserves and in consumption. There has been considerable outrage from the Western world over the air quality in China due to the lack of environmental regulations. I can confirm firsthand that air pollution there is bad. The good news is that Beijing looks ready to pass laws to improve its air quality. The centerpiece is expected to be an import ban on low-quality coals with a caloric content of less than 3,900 kilocalories per kilogram. Such coals, like lignite, are used in lower-tech power plants. China recently surpassed Japan as the largest importer of coal, even with Japan’s post-Fukushima scramble to replace the electricity that its nuclear power plants used to produce. Tokyo Gas, Japan’s largest municipal natural gas utility, said it has “strong interest” in building new coal-fired plants in order to diversify energy supply—a nice bump for coal demand in the country. Country Australia United States South Africa Eurasia Canada Indonesia The Long and Short of It When a company uses the abbreviation “t,” remember that this refers to the metric ton, also known as the long ton. Standard engineering reports designate these as tonnes, but all the terms mean 1,000 kilograms, or 2,204 pounds. It’s the short ton that equals 2,000 pounds. So when comparing production, for instance—most often between US and non-US companies—be sure your apples are lined up against apples, not oranges. We have the one company that is best positioned to return significant returns to shareholders. In fact, our existing subscribers are sitting on profits with this company, and we think it’s only going to get better, even when other coal companies are going bankrupt. If you want to read more details about this winner and get our ongoing guidance on this and many other blockbuster energy companies, consider trying my monthly newsletter, the Casey Energy Report risk-free for 3 months. You have nothing to lose: if you aren’t 100% satisfied—for whatever reason—simply cancel within those 3 months for a full and prompt refund. Even if you cancel any time after the 3 months are up, you’ll still receive a prorated refund on the rest of your subscription. I’m so confident that you’ll find the Casey Energy Report to be a great value for the price that I have no problem giving out a 3-month test drive. If for whatever reason you don’t like it, no worries: you get 100% of your money back. If you like it and make money, I know you’ll stay a happy subscriber. You deserve to be rich, and if you want to learn about energy, the Casey Energy Report is the best place to start. Click here to get started today. Region Australia United States South Africa Eurasia S. America Indonesia Exports (millions of tons) 327.2 95.5 122 137.8 224.7 531.2 Given a specific amount of resource, you might wonder how much of it is actually being produced. A common metric that reveals the number of years left at current production rates is the reserves-to-production ratio—a country’s total proven and probable reserves divided by its annual production. It’s not just the quantity, but the kind of coal that matters. Calories quantify the amount of heat produced by complete combustion of the material—in effect, the amount of energy the material contains. In the case of coal, caloric level represents its quality, ash and moisture content, and its hardness. A major reason why anthracite and bituminous coals are more valuable resources is their high caloric content. The following chart combines these two characteristics per country.last_img read more

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In a windowless classroom at the John J Moran med

first_imgIn a windowless classroom at the John J. Moran medium-security prison in Cranston, R.I., three men sit around a table to share how and when they began using opioids.For Josh, now 39, it was when he was just 13 years old. “I got grounded for a week in my house, so I grabbed a bundle of heroin and just sat inside and sniffed it all week.””I started using heroin at 19,” says Ray, now 23. “I was shooting it. It was with a group of friends that I was working with, doing roof work.””At 26 years old, I experimented with heroin,” says Kevin, 50. “I wasn’t the person that I wanted to be. Once I put that in my system, I felt like this is what I’m supposed to do and this is what I’m supposed to feel like.”This group therapy session is part of a $2 million program the Rhode Island Department of Corrections launched in 2016. These men are all serving prison sentences for crimes driven by their drug addiction — including robbery, shoplifting and possession of controlled substances. NPR agreed to only use their first names so they could speak frankly about illegal behavior.They are among the approximately 275 inmates and pretrial detainees getting medication-assisted treatment behind bars.The program is central to Rhode Island Gov. Gina Raimondo’s strategy to reduce opioid overdose deaths in the state. Today, Rhode Island remains the only state to screen every individual who comes into the correctional system for opioid use disorder, and to offer, along with drug counseling, all three types of drugs approved by the Food and Drug Administration to treat addiction — methadone, buprenorphine and naltrexone.While prisons have long offered medication-assisted treatment to small subsets of inmates, such as pregnant women, many prisons in the U.S. do not offer it at all, despite the fact that it’s considered by physicians to be the most effective treatment for opioid addiction.The criminal justice reform bill currently before Congress would require the Federal Bureau of Prisons to assess its capacity to provide medication-assisted treatment to inmates who are dependent on opioids, and to draw up plans to expand access to medically aided treatment “where appropriate.” But the bill leaves open who would determine when and where the medication is appropriate.”It’s just ludicrous that we have a whole population of people who are by and large incarcerated because of their disease, and we have an effective medication treatment for the disease and we don’t give it to them,” says Dr. Josiah Rich, director of the Center for Prisoner Health and Human Rights at the Miriam Hospital in Providence.Rich was one of the experts tapped by Raimondo to identify where best to direct resources to bring down the state’s overdose deaths. He made the case for a prison program, given the high death rate among people recently incarcerated.”This is a population of the most severely impacted, the most advanced stages of opioid use disorder — the people who have taken the greatest risks and gotten caught up in the system,” Rich says. While in prison, the inmates’ opioid use usually ends, and so does their ability to tolerate high doses of the drugs without overdosing.”Then you get released into a very stressful situation with a lot of triggers, and you typically relapse,” Rich says. “And if you relapse back to the same level you were using, you’re set up for overdose and death.”This is what drove the Rhode Island Department of Corrections to offer medication-assisted treatment not just to people coming into prison, but also to those who began serving their sentences before the program existed. Eight to 12 weeks before their release, inmates with histories of addiction are offered methadone, buprenorphine or naltrexone to ease their transition back to society, beginning with very low doses.”Even if somebody has not used in many years, they may still have changes in their brain,” says Dr. Jennifer Clarke, the Department of Corrections medical programs director. “The cravings are always going to be there. So, if somebody’s going back to the same old neighborhood, chances are they’re going to be exposed to the same people as when they were using drugs.”So, providing the medication before someone gets out really helps to prevent a relapse,” Clarke says.The possibility of relapse is top of mind for the men in group therapy. They have friends who have overdosed and died after serving time.Kevin has just a few weeks left in his sentence, one of many that he’s served in his adult life. “It feels good, but I’m nervous. I always get nervous,” he says. “As soon as I walk out the gates — my feet, when they hit the pavement outside of here, I have to get busy immediately.””You worry about the drug aspect once you hit the street,” says Josh who has also served multiple sentences for drug-related crimes. “Many times, I’ve gone out of here and overdosed repeatedly. Not on purpose, just accidentally, trying to hide from the pain, hide from myself.”This time, Josh says, the treatment program has given him a way to focus on a different way out.”I still have to fight the other drugs,” he says. “But at least I have something to help with one of the ones that’s brought me closer to death than anything else.”The program inside the prison is run by CODAC, a behavioral healthcare organization that also runs substance abuse treatment programs outside the prison, with locations across Rhode Island. Prisoners who enter the program remain clients when they exit prison, with treatment outside typically paid for by Medicaid. Discharge planners from CODAC help the inmates get organized for that transition.”I already have counseling appointments lined up, doctors appointments lined up,” says Ray, who is scheduled to be released in December. In prison, he’s been taking buprenorphine, which he’ll continue the day he gets out. “I really don’t want to use heroin again.”Early reports from the program are promising. In a study published in JAMA Psychiatry last spring, researchers found that overdose deaths among people who had recently been imprisoned dropped sharply in the first six months of 2017 as compared to the same period the year before — nine deaths, compared to 26.Researchers continue to track outcomes and are interviewing inmates and correctional staff to learn more about how well the program is functioning.There have been hurdles to overcome, says Lauranne Howard, substance abuse coordinator for the Department of Corrections, starting with resistance from security staff about the use of buprenorphine in the program. Buprenorphine itself is an opioid, though less potent than street drugs in many of its effects, and sometimes ends up sold or given to people outside its intended use.”The reaction was, why are you going to bring in a medication that we’re working real hard to keep out? And that’s a legitimate concern,” Howard says.In response, the program has made some changes. CODAC’s Leslie Barber, who directs the prison program and runs the group therapy sessions, says they launched the program using buprenorphine pills, which take awhile to dissolve.”We compromised by switching to the films which, although more expensive, dissolve quicker,” she says. CODAC says the buprenorphine pills cost approximately $4 each, while the films cost approximately $8 each.A number of other states have taken notice and sent corrections officials to Rhode Island to learn from their experiences. Clarke points out that Rhode Island has the advantage of being a small state with a combined jail and prison system, so that everyone who is incarcerated comes to the same campus.”Places like Rikers Island [in New York City] have all three types of medication for opiate use disorder, but they can’t start people who might have a prison sentence, because they’re going to be sent to a different facility, and they don’t have the same opportunities to continue treatment that we have,” Clarke says.Patricia Coyne-Fague, acting director of corrections for Rhode Island, recognizes that even with this program, people will stumble and make mistakes — even end up reincarcerated. Still, she defends the $2 million annual expenditure with the argument that the program saves lives.”Sometimes there can be a negative attitude about whose lives we are saving,” she says. “But everybody belongs to somebody. And so, while they may have committed a crime and deserve to be incarcerated, they’re still human beings. And if we can keep people from dying, that’s a good thing.” Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

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7 Things Entrepreneurs Need to Know About the State of Venture Capital

first_img 2 min read April 5, 2017 Software, life sciences and biotech are among the industries getting the most love. Entrepreneur Staff Nina Zipkin Add to Queue Image credit: Shutterstock.com 7 Things Entrepreneurs Need to Know About the State of Venture Capital Learn how to successfully navigate family business dynamics and build businesses that excel.center_img Staff Writer. Covers leadership, media, technology and culture. Raising venture funding is never easy, but it would seem that the industry as a whole is trending in a positive if more measured direction.While there has been a slight increase in the amount of money that was invested in the first three months of 2017 compared to the last quarter of 2016, the number of companies that received funds hasn’t been this low since quarter four of 2011, according to PitchBook-Venture Monitor, a quarterly report.“It’s easy to look at the numbers and assume the industry is starting to lose its footing, but we don’t think that’s the case,” said John Gabbert, founder and CEO of PitchBook, which along with National Venture Capital Association (NVCA) publishes the report. “We see this as investors and entrepreneurs returning to a more disciplined approach to investing. Both parties are having to exercise more caution in the market and conduct the necessary due diligence to pencil out fair deals on both sides.”Related: 3 Shifts That Signify Where Venture Capital Is Headed This YearHere are a few facts to get up to speed on the state of the venture capital industry:In the first quarter of the year, venture capitalists invested $16.5 billion in 1,797 companies.Angel and seed investments were down from this time last year: 827 deals were recorded completed in the first quarter of 2017 compared to 1,223 in the first quarter of 2016.Two of the industries that saw the biggest amount of investments were life sciences and software. They saw the majority of deals, with 930 completed in the first quarter of 2017.The industries that had the most exits in Q1 2017 were software, biotech and commercial services, which accounted for 73 percent of total exits.VCs invested in companies in 46 states and the District of Columbia.Half of all the capital distributed in the first quarter, $8.3 billion, went to 560 companies in California.Sixty-nine percent of all the startups in the U.S. that received investment were outside of California. Free Webinar | July 31: Secrets to Running a Successful Family Business Register Now » Venture Capital Next Article –shareslast_img read more

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Is LinkedIn Trying to Catch You Lying on Your Resume Maybe

first_img The only list that measures privately-held company performance across multiple dimensions—not just revenue. Is LinkedIn Trying to Catch You Lying on Your Resume? Maybe. Apply Now » Linkedin Add to Queue –shares This story originally appeared on Fortune Magazine 2 min readcenter_img Kia Kokalitcheva Image credit: dolphfyn | Shutterstock.com April 22, 2015 Next Article LinkedIn may be on a mission to clean its professional network of fibs and incorrect facts, at least according to a new patent application the company filed Tuesday.The filing is for a fact-checking system that would catch inaccuracies that users type in as well as give them the correct information. In one simple example, the company listed the possibility of a user who enters Texas as the largest state only to be told that it’s actually Alaska.The 82-page document, filed with the U.S. Patent and Trademark Office, covers a wide variety of situations, types of information, and ways in which the system could automatically fact-check information. But three main uses are obvious.LinkedIn is increasingly a destination for news articles, blog posts, and user-generated content that the company would be well-served to clean of mistakes and purposely false information. The company recently announced Elevate, a new app that suggests articles and content for users to share on LinkedIn and other social networks.Although the application made no explicit mention of it, LinkedIn could also apply the fact-checker to its users’ professional profiles. LinkedIn has long been known as the “online resume” and oftentimes, professionals use their profiles in the network as a way to promote their accomplishments.Those resumes can also be filled with deceit and mistakes, and so far, LinkedIn users have been on the honor system. Although it would be difficult or impossible for it to verify some claims, others could easily be compared against publicly available information online or in private databases that LinkedIn could buy or license.And lastly, it could also be helpful to LinkedIn’s latest acquisition: online learning company Lynda. Students could conceivably get automated feedback on interactive homework and quizzes. 2019 Entrepreneur 360 Listlast_img read more

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How to Watch the Rio 2016 Olympics Online

first_img August 5, 2016 Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Enroll Now for $5 This story originally appeared on PCMag The 2016 Rio Olympics are going to be something to watch, from the unfolding controversies to the uplifting stories of athletes making their way to Brazil.There are 19 days of Olympics viewing, from women’s soccer on Aug. 3, two days before the opening ceremony to the closing ceremony on Aug. 21. Daytime programming will be from 10 a.m. to 5 p.m., primetime 8 p.m. to midnight, late-night from 12:35 a.m. to 1:35 a.m., and replays from 1:35 a.m. to 4:30 a.m. Despite the games bringing together competitors from around the world, coverage is not so universal. The International Olympic Committee will not show the games on its YouTube channel until they are over, but there are other options.NBCOlympics.com has live streams, replays, and all sorts of extras, but you have to be a cable TV subscriber to access it all. NBC will again allow viewers to watch 30 minutes of video before signing in, though.Other countries will have coverage that you won’t see on NBC in the US. If you want to watch any of the over 100 broadcasters worldwide, you can use a VPN service, like Hola, but proceed at your own risk.NBC SportsThe NBC Sports app contains coverage from NBC, NBC Sports Network, and the Golf Channel. The app is available for iOS, Android, and Windows.Telemundo DeportesThe Telemundo Deportes app has Telemundo’s coverage to go. It’s available for iOS and Android.StreamingFor watching the games from the comfort of the couch, you can use a set-top box or gaming console. The NBC Sports app works on Android TV, Apple TV, Roku and Xbox. There is no app for Chromecast, but you can cast your browser to your TV. For PlayStation users, you have to subscribe to PlayStation Vue.SlingIf you’re a Sling Blue customer, then you get live coverage from NBC (if it’s available on Sling in your area) NBCSN, Bravo and USA. As with all Sling services, you can watch on your computer, mobile device, set-top box and gaming console. Image credit: PC Mag Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Chandra Steele 32shares Next Article Olympics How to Watch the Rio 2016 Olympics Online Senior Features Writer, PCMag Add to Queue 2 min readlast_img read more

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Leanplum and Amplitude Partner to Deliver HyperTargeted Mobile Campaigns

first_imgDual Platform Analysis Enables Marketers to Tailor Behavior-Driven Campaigns for Radically Improved EngagementLeanplum, the leader in mobile marketing engagement and Amplitude, the leader in Product Intelligence, announced a fully integrated partnership that enables users to simultaneously harness the power of both platforms to optimize mobile marketing campaigns and accelerate product improvements.Marketing teams can now use Leanplum to run personalized campaigns to different user personas across all mobile marketing channels.  Then, tapping into Amplitude’s comprehensive product analytics, clients can surface actionable usage insights and increase the impact of campaign reruns. Trends in user behavior and triggers that lead to the desired user outcome are easily identified through Amplitude and used to create behavioral cohorts that can be targeted with the Leanplum platform for improved KPIs.Furthermore, new product features can be tested before they are released, and experiences can be personalized for various user segments. As a result, product improvements are accelerated and move beyond a one-size-fits-all approach to create a personalized experience for users and drive end-to-end growth.Marketing Technology News: IBM Releases AI-Powered Anomaly Detection Capabilities to Mitigate Supply Chain DisruptionsThe Leanplum and Amplitude dynamic feedback loop enables bi-directional data to be transmitted between the two platforms and allows marketing teams to analyze user behavior to create tailored, behavior-driven campaigns. Leanplum-generated data from mobile campaigns and A/B tests are intuitively exported into Amplitude’s platform for advanced behavioral analyses. Lookalike audiences can then be exported back into Leanplum’s platform to improve campaign reach and efficacy.With Leanplum and Amplitude you can:Align in-app experience with messaging campaigns to drive end-to-end growthConduct A/B testing of product features and identify which variants drive desired behaviorsUnderstand in real-time the effect of campaigns on critical metrics around adoption, engagement conversion, retention and lifetime user value (LTV)Identify lookalike personas to uncover more users who will respond favorably to a campaignAdjust strategy based on a deep understanding of user behaviorMarketing Technology News: Verve Reaffirms Commitment To Fraud-Free Media With Pixalate Partnership And TAG Recertification“Understanding the intricacy and diversity of user behavior is key to driving successful campaigns,” said Ed Sullivan, SVP, Global Alliances & Partnerships of Leanplum. “We’re delighted to partner with Amplitude to deliver an even stronger and more real-time analysis of how audiences engage with campaigns and in-app experiences for improved conversion, retention, adoption and feature roll-out.”“The detailed behavioral insights into the full user experience journey we provide helps our customers rapidly build and improve digital products and grow their business,” said Tai Rattigan, VP of Global Partnerships of Amplitude. “Partnering with Leanplum enables us to expand upon our data-driven approach to product development by integrating insights into personalized multichannel campaigns for improved KPIs.”Marketing Technology News: TextUs Introduces the “Text Us” Call to Action — the Evolution of the “Contact Us” That Lets Customers Text Message Businesses Leanplum and Amplitude Partner to Deliver Hyper-Targeted Mobile Campaigns PRNewswireMay 16, 2019, 7:32 pmMay 16, 2019 AmplitudeLeanplumlifetime user valueMarketing Technologymobile marketingNewsProduct Intelligence Previous ArticleHGC Further Collaborates with Salesforce and Enxoo to Accelerate Digital Transformation and Deliver a Better Customer ExperienceNext ArticleOutlier Expands Scope of Business Data for Data Scientists and Analysts with New Announcementlast_img read more

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Researchers develop new molecule that halts progression of heart failure

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 13 2019A group of researchers based in Brazil and the United States have developed a molecule that halts the progression of heart failure and improves the heart’s capacity to pump blood.Rats with heart failure were treated for six weeks with the molecule, called “SAMβA.” The disease not only stabilized, as it usually does in response to conventional drug therapy, but actually regressed, thanks to an improvement in the contractile capacity of the cardiac muscle.Heart failure may result from myocardial infarction, commonly known as a heart attack, when a blocked coronary artery prevents blood from reaching a section of the heart. The rest of the cardiac tissue is overloaded, and the heart’s capacity to pump blood throughout the body gradually declines over time.The researchers have applied for a patent on SAMβA and its use in the United States. The molecule may come to supplement or even replace the medications currently used to treat heart failure, most of which were developed back in the 1980s.An article describing SAMβA has been published in Nature Communications. The name SAMβA stands for “selective antagonist of mitofusin 1-β2PKC association,” referring to the molecule’s capacity to inhibit the interaction between protein kinase C beta 2 (β2PKC), a common protein in heart cells, and mitofusin 1 (Mfn1), a key element of mitochondria, which are the organelles that produce energy for cells.In this interaction, β2PKC inhibits Mfn1, preventing the mitochondria from producing energy and hence weakening the heart’s blood-pumping action.”This interaction was one of our main findings in this study. Its critical role in the progression of heart failure was previously unknown,” said Julio Cesar Batista Ferreira, a professor at the University of São Paulo’s Biomedical Science Institute (ICB-USP) in Brazil and principal investigator for the study. Ferreira began research in the field in 2009 when he was a postdoctoral fellow at the same university’s School of Physical Education and Sports (EEFE-USP) with a scholarship from FAPESP – São Paulo Research Foundation.Once the patent has been granted, Ferreira added, the molecule can be tested in connection with hypertension and other cardiovascular diseases.”We suspect the interaction between these two proteins may be a factor in other degenerative diseases involving mitochondrial dysfunction,” Ferreira told Office.Clerk and managersPrevious research by Ferreira’s group at ICB-USP showed that the inhibition of β2PKC, which is overproduced in the cells of failing hearts, improved cardiac function in these patients. However, the intervention prevented the protein from acting in other ways that benefit the heart.The novelty of SAMβA is its selectivity: it inhibits only β2PKC’s interaction with Mfn1 in mitochondria and does not affect the protein’s other actions.Ferreira offers an analogy to explain this selectivity, comparing a heart cell to a company office with several rooms. β2PKC is an office clerk who moves along the corridors and goes into the different rooms, interacting with the managers of the respective sectors to perform his/her duties. When he/she enters one particular room (the mitochondrion), however, the office clerk (β2PKC) prevents a particular manager (Mfn1) from doing his/her job.Related StoriesTeam approach to care increases likelihood of surviving refractory cardiogenic shockAntioxidant precursor molecule could improve dopamine levels in Parkinson’s patientsResearchers discover novel cancer-promoting molecular mechanismWith the first molecule developed by the group, it was as if the doors of all the rooms were closed. The office clerk no longer hampered the mitochondrial manager and did not enter any other rooms; the company (heart cell) did not function harmoniously.However, all SAMβA does is prevent β2PKC from interacting with Mfn1 in mitochondria. “It’s as if we only closed the door to the room the clerk isn’t allowed to enter while leaving him free to go into all the others, so the company can continue functioning properly,” Ferreira said.Infarcted ratsTo arrive at SAMβA, the researchers performed tests with recombinant proteins, cells, animals, and samples of cardiac tissue from patients with heart failure.Ferreira’s group first conducted different in vitro experiments to test the interaction between β2PKC and Mfn1. They found six molecules that inhibited the interaction, but only SAMβA did so selectively without influencing other interactions.Next, SAMβA was tested in human heart cells. In addition to halting the progression of the disease, which is already achieved by the drugs currently in use, the molecule boosted the cells’ capacity to contract – an essential part of the job done by the heart in pumping blood throughout the body.SAMβA also reduced the amount of hydrogen peroxide in heart cell mitochondria. The presence of this peroxide characterizes oxidative stress, which is a trigger of cardiac cell degeneration.Finally, the researchers induced myocardial infarction in rats. One month later, the rats developed heart failure, and an osmotic pump was implanted under the skin of each rat to release small amounts of SAMβA or an innocuous substance (in the case of the control group) for six weeks.Unlike the control rats, those that were treated with SAMβA stopped exhibiting heart failure, and their cardiac function improved.”The drugs in current use halt progression of the disease but never make it regress. We showed that by regulating this specific interaction, we could both halt progression and make the disease regress to a less severe stage,” Ferreira said.The next step is to make SAMβA available to other research groups for testing against other diseases in different experimental models. It will also be necessary to test the molecule’s interaction with the drugs now used to treat heart failure.”Validation and reproduction of our findings by other groups are critical to the process of developing SAMβA for use in treating heart failure. We will be seeking partners in the private and public sectors for this purpose,” Ferreira said.Cardiovascular diseases kill 17.9 million people annually, causing 31% of all global deaths, according to the World Health Organization (WHO). Acute myocardial infarction with subsequent heart failure is a major cause of morbidity and mortality worldwide.Source: http://agencia.fapesp.br/researchers-create-a-new-molecule-to-treat-heart-failure/29842/last_img read more

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Common medications to treat heartburn linked to increased risks for kidney failure

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 19 2019Common medications prescribed to treat heartburn, acid reflux and ulcers are linked to increased risks for kidney failure and chronic kidney disease, found a recent University at Buffalo study.Use of proton pump inhibitors (PPI), a group of drugs that reduce the production of stomach acid, increases the risk of chronic kidney disease by 20 percent and raises the risk of kidney failure by four times. Risks were highest among people at least 65 years old.The research, published in February in Pharmacotherapy, is one of the first large, long-term studies to examine the effects of PPIs on kidney function. Researchers examined the health data of more than 190,000 patients over a 15-year period.Related StoriesChronic kidney disease patients are excluded from clinical trialsSchwann cells capable of generating protective myelin over nerves finds researchArtificial intelligence can help accurately predict acute kidney injury in burn patients”This study adds to a growing list of concerning side effects and adverse outcomes associated with PPIs,” says David Jacobs, PharmD, PhD, lead investigator and assistant professor of pharmacy practice in the UB School of Pharmacy and Pharmaceutical Sciences.”Given the increasing global use of PPIs, the relationship between PPIs and renal disease could pose a substantial disease and financial burden to the health care system and public health.”PPIs are one of the most commonly prescribed medications in the U.S., with an estimated 113 million prescriptions filled in 2008, costing patients nearly $14 billion, says Jacobs.Due to acid reflux and related conditions only requiring short-term treatment with PPIs, he adds, up to 70 percent of patients overuse these medications without benefit and are subjected to unnecessary adverse effects.The prevalence of PPI use in the U.S. could have a devastating effect on public health. Because these drugs are still considered safe, education and deprescribing initiatives are needed to raise awareness among health care providers, says Jacobs. Deprescribing may involve reducing dosage or stopping usage.Data for the investigation was gathered from medical insurance and prescription claims from a Western New York insurer. Researchers examined medical history from 1993-2008 of adult patients with no history of kidney disease.Kidney health was compared between patients who underwent PPI therapy and those who were unexposed. Examined PPIs included esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole (commonly known by brand names as Vimovo, Prevacid, Prilosec, Protonix and Aciphex, respectively). Source:buffalo.edu/news/releases/2019/03/0220.htmllast_img read more

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